Multimarker Screening of Oxidative Stress in Aging

Table 1

Age-related diseases and detected biomarkers.

Disease	Biomarkers	Body fluid/tissue
Alzheimer’s disease	3-Chlorotyrosine	Hippocampus proteins [14]
	3-Nitrotyrosine	Brain [15]
		Cerebrospinal fluid [16, 17]
	8-Hydroxy-2′-deoxyguanosine	Brain [18]
	8-Hydroxyguanosine	Brain [18]
		Blood serum [19]
		Cerebrospinal fluid [19]
Arthritis	8-Isoprostane	Blood plasma [20]
		Urine [20]
	3-Nitrotyrosine	Blood serum [21, 22]
		Synovial fluid [22]
	8-Hydroxy-2′-deoxyguanosine	Blood plasma [23]
		Synovial fluid [23]
		Urine [24]
Atherosclerosis	3-Chlorotyrosine	Human aortic tissue [25]
	3-Nitrotyrosine	Atherosclerotic blood vessels [26]
	8-Hydroxy-2′-deoxyguanosine	Urine [27]
Cataracts	8-Isoprostane	Blood plasma [28]
	o-Tyrosine	Cataractous lenses [29]
	m-Tyrosine	Cataractous lenses [29]
	8-Hydroxy-2′-deoxyguanosine	Blood plasma [30]
Hypertension	8-Isoprostane	Blood plasma [31, 32]
	3-Nitrotyrosine	Lung tissue [33]
	8-Hydroxyguanosine	Lung tissue [33]
	8-Hydroxy-2′-deoxyguanosine	Urine [34]
Osteoporosis	8-Hydroxy-2′-deoxyguanosine	Blood serum [35]
Type II diabetes	8-Isoprostane	Blood plasma [36, 37]
		Urine [38]
	o-Tyrosine	Blood plasma [39]
		Urine [39]
	8-Hydroxy-2′-deoxyguanosine	Blood serum [40]
		Urine [38]