Multimarker Screening of Oxidative Stress in Aging

Table 3

Functional changes of nitrated proteins, adapted from [71] (shortened version).

Protein	Normal activity	Activity after nitration
Cytochrome c	Electron transfer and apoptosis	Higher peroxidatic activity [74, 75]; Decreased apoptosome activation [78]
Fibrinogen	Coagulation	Higher aggregation [76]
Protein kinase C𝜀	Serine/threonine kinase	Translocation and activation [77]
𝛼-Synuclein	Presynaptic protein	Higher aggregation [79]
Nerve growth factor	Neurotrophic factor	Neuronal apoptosis [80]
MnSOD	Superoxide dismutation	Decreased activity [72]
Prostacyclin synthase	Synthesis of prostacyclin	Decreased activity [73]
Tyrosine hydroxylase	Synthesis of L-DOPA	Decreased activity [81]
Protein kinase C	Serine/threonine kinase	Decreased activity [82]