Oxidative Stress in Aging: Advances in Proteomic Approaches

Figure 2

Alteration of proteins by oxidative damage and their turnover. The balance between functional proteins, present in young or healthy organisms, and detrimental or altered proteins, present in a large proportion of aged or diseased organisms, depends mainly on their modification and turnover. If proteins are affected by an increase in oxidative damage or by a low protein turnover, altered proteins accumulate, in contrast to when oxidative damage diminishes and protein turnover increases, when functional proteins increase their proportion and the organism transits to a healthy stage.