Lentivirus-Mediated Nox4 shRNA Invasion and Angiogenesis and Enhances Radiosensitivity in Human Glioblastoma
Figure 3
Effect of Nox4 silencing on radiosensitivity of glioblastoma cell lines was measured by clonogenic survival assay. Colony-forming efficiency was determined 10 to 14 d later and survival curves were generated and linear-quadratic (LQ) equation was fitted to data sets. (a) U87MG infected with Nox4-shRNA or scrambled control (DEF0.1 = 1.267 when shRNA versus scrambled control). (b) U251 infected with Nox4-shRNA or scrambled control (DEF0.1 = 1.347 when shRNA versus scrambled control). Points, mean; DEF, dose enhancement factor.
