The Effects of Quinacrine, Proglumide, and Pentoxifylline on Seizure Activity, Cognitive Deficit, and Oxidative Stress in Rat Lithium-Pilocarpine Model of Status Epilepticus

Table 1

Dose-dependent antiepileptic activity of pentoxifylline (Ptx), proglumide (Pgm), and quinacrine (Qcn) against Li-Pc induced status epilepticus (SE) in adult rats.

Behavioral parameters observed	Control	Ptx (mg/kg)			Pgm (mg/kg)			Qcn (mg/kg)
		20	40	60	250	500	750	5	15	30
Latency to seizures (min)	9.62 ± 1.20	14.59^ns ± 1.42	24.62^a ± 2.44	38.15^a ± 1.80	12.46^ns ± 1.17	22.47^a ± 1.59	35.33^a ± 1.64	10.21^ns ± 1.42	19.38^a ± 2.61	31.72^a ± 1.53
Seizures (%)	100	85.0	55.0^a	10.0^a	85.2	61.3^a	21.3^a	87.4	66.5^a	29.8^a
Latency to SE (min)	23.86 ± 1.54	34.61^a ± 0.86	48.70^a ± 0.96	No SE	32.52^a ± 1.07	44.61^a ± 1.22	56.11^a ± 2.63	29.62^a ± 1.61	40.33^a ± 2.57	58.8^a ± 1.91
SE (%)	100	50.0^a	20.0^a	0^a	61.4^a	36.8^a	23.5^a	68.3^a	39.2^a	25.4^a
Mortality (%) within 24 hours	10	0	0	0	0	0	0	0	0	0

Animals were observed for more than 1 h after Li-Pc (lithium-pilocarpine) injections for inducing SE in all groups, and all animals were observed for more than 24 hours for mortality.
^nsStatistically nonsignificant.
^a as compared to control (0 mg/kg) by ANOVA followed by Student-Newman-Keuls Multiple Comparisons Test.