Oxidative Stress and Histological Changes in a Model of Retinal Phototoxicity in Rabbits
Figure 3
Phototoxicity induces apoptotic death and activation of inflammatory processes. ((a)–(c)) Caspase-3 immunohistochemistry showed no staining in control (a) and LEW rabbit retinas (c); however we found positive caspase-3 cells in the INL in LE rabbit retinas ((b) arrowheads). ((d)–(f)) Caspase-1 immunohistochemistry. Control rabbit retinas showed no caspase-1 staining (d). Labeling was seen (arrowheads) in LE (e) and LEW rat retinas (f). Scale bar: 50 μm. Retinas were contrasted with hematoxylin. (ONL) Outer nuclear layer, (OPL) outer plexiform layer, (INL) inner nuclear layer, (IPL) inner plexiform layer, and (GCL) ganglion cell layer.
