Oxidative Stress and Histological Changes in a Model of Retinal Phototoxicity in Rabbits
Figure 5
Superoxide generation was assessed in rabbit retinas with the fluorescent indicator DHE (red). (a) Confocal microscopic image of a rabbit retina from the control group. (b) DHE was detected in the LE group (arrowhead) at the ONL. (c) DHE fluorescence in the retinas from the LEW group was significantly lower. Staining of cell nuclei was observed for TO-PRO-3 (blue). Arrows indicate the ONL where the DHE was strong. Scale bar: 50 μm. (ONL) Outer nuclear layer, (OPL) outer plexiform layer, (INL) inner nuclear layer, (IPL) inner plexiform layer, and (GCL) ganglion cell layer.
