Effect of the French Oak Wood Extract Robuvit on Markers of Oxidative Stress and Activity of Antioxidant Enzymes in Healthy Volunteers: A Pilot Study
Table 1
Markers of oxidative stress, activity of antioxidant enzymes, and total antioxidant capacity after weeks 0, 4, and 6.
Parameter
Week 0
Week 4
(0 versus 4)
Week 6
(0 versus 6)
AOPP (mol/L)
58.06 (49.32; 59.27)
33.62 (30.49; 35.56)
<0.0001
33.18 (28.44; 34.03)
<0.0001
PC (ng/mL)
0.296 ± 0.059
0.288 ± 0.052
n.s.
0.273 ± 0.054
0.0037
AGEs (AU/g prot.)
273.17 (249.01; 305.33)
296.17 (237.34; 323.05)
n.s.
286.07 (258.07; 322.95)
n.s.
8-oxoG/106 G
0.61 (0.35; 0.91)
0.79 (0.47; 1.43)
n.s.
0.78 (0.38; 1.62)
n.s.
8-isoP (pg/mL)
24.59 (21.16; 33.77)
34.02 (24.16; 39.01)
n.s.
31.63 (23.98; 44.66)
n.s.
LP (nmol/mL)
42.55 (33.6; 61.54)
33.39 (28.17; 44.19)
0.0174
34.13 (28.10; 48.37)
0.0038
SOD (U/mg Hb)
42.42 ± 6.83
47.41 ± 9.93
0.0198
48.03 ± 5.27
0.0240
CAT (kat/g Hb)
5.60 (4.76; 6.12)
6.47 (6.11; 7.41)
0.0012
4.59 (3.72; 6.46)
n.s.
GPx (U/g Hb)
39.55 ± 9.16
40.74 ± 8.23
n.s.
36.21 ± 8.96
n.s.
ORAC (mmol/L)
8.97 (8.34; 9.61)
8.72 (8.03; 9.67)
n.s.
8.69 (8.08; 9.72)
n.s.
FRAP (mmol/mL)
0.586 ± 0.098
0.623 ± 0.115
0.0091
0.603 ± 0.124
n.s.
Data are presented as mean ± SD or median and IQ range (1st quartile; 3rd quartile); AOPP: advanced oxidation protein products; PC: protein carbonyls; AGEs: advanced glycation end-products; AU: arbitrary units; 8-isoP: 8-isoprostanes; LP: lipid peroxides; SOD: Cu/Zn-superoxide dismutase; CAT: catalase; GPx: glutathione peroxidase; ORAC: oxygen radical absorbance capacity; FRAP: ferric reducing ability of plasma; : significant; n.s.: not significant ().
