Oxidative Medicine and Cellular Longevity / 2014 / Article / Fig 4

Research Article

Mitochondria-Targeted Antioxidant Prevents Cardiac Dysfunction Induced by Tafazzin Gene Knockdown in Cardiac Myocytes

Figure 4

Mito-Tempo inhibited tafazzin knockdown induced protein kinases. NVMs were transduced with the shRNA adenovirus for 48 h, treated with 25 μM mito-Tempo (mito-TP) or Tempol (TP) for the last 24 h, and tested for phosphorylated AMPKα ((a) and (c)) and JAK2 ((b) and (d)). Data represent mean ± SE of 5 or 3 separate experiments for p-AMPKα with the treatments of mito-TP or TP and 4 separate experiments for JAK2 with the treatments mito-TP or TP. and versus SCR treated with vehicle. versus Taz knockdown cells treated with vehicle.

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