Mitochondria-Targeted Antioxidant Prevents Cardiac Dysfunction Induced by Tafazzin Gene Knockdown in Cardiac Myocytes
Figure 7
Mito-Tempo abrogated cytochrome c release and cell death induced by tafazzin knockdown. NVMs were transduced with the shRNA adenovirus for 48 h, mito-Tempo treated for the last 24 h, and tested for mitochondrial cytochrome c content and cell death. (a) Mitochondrial cytochrome c content. Data represent mean ± SE of 4 separate experiments. versus SCR treated with vehicle. (b) Cell count. Data represent mean ± SE of three separate experiments. versus vehicle.