Leucocyte Telomere Shortening in relation to Newly Diagnosed Type 2 Diabetic Patients with Depression

Table 1

Demographic, clinical, and biochemical parameters of the study subjects of T2D and Ctrl.

	T2D; 𝑛=71	Ctrl; 𝑛=52	𝑃
Age (yrs)	54.55±8.37	51.27±7.66	0.028
Male [(𝑛 (%)]	40 (56.34)	30 (57.69)	0.881
Current smokers [(𝑛 (%)]	21 (29.58)	14 (26.92)	0.784
Current drinkers [(𝑛 (%)]	13 (18.31)	8 (15.38)	0.670
Use of aspirin [(𝑛 (%)]	8 (11.27)	4 (7.69)	0.509
Use of statin [(𝑛 (%)]	7 (9.86)	4 (7.69)	0.677
Use of antihypertensive drugs[(𝑛 (%)]	6 (8.45)	5 (9.62)	0.823
HADS-D score (point)*	8 (6, 9)	8 (6, 9)	0.200
HADS-D ≥ 10 [(𝑛 (%)]	17 (23.9)	5 (9.6)	0.041
BMI (kg/m^2)	25.21±2.19	23.86±1.47	0.000
Waist circumstance (cm)	87.5 (81.8, 94.0)	82.0 (78.0, 86.0)	0.000
WHR	0.84 (0.77, 0.89)	0.80 (0.74, 0.84)	0.000
Systolic blood pressure (mmHg)	132 (120, 141)	127 (123, 130)	0.040
Diastolic blood pressure (mmHg)	81 (75, 88)	74 (68, 80)	0.000
HbA1c (%)	8.29 (7.58, 8.90)	5.10 (4.80, 5.40)	0.000
FPG (mmol/L)	8.72±1.39	5.44±0.35	0.000
FIN (mIU/L)	11.44 (6.99, 13.29)	12.22 (7.8, 14.32)	0.520
HOMA-IR	4.51 (2.73, 5.54)	2.93 (2.00, 3.29)	0.000
Total cholesterol (mmol/L)	4.69±0.90	4.05±0.54	0.000
Triglyceride (mmol/L)	1.86 (1.12, 2.31)	1.20 (0.86, 1.32)	0.000
HDL-cholesterol (mmol/L)	1.15±0.24	1.22±0.27	0.020
LDL-cholesterol (mmol/L)	2.47±0.78	2.21±0.67	0.050
8-OHdG (ng/mL)	1.75±0.51	1.16±0.31	0.000
T/S ratio	2.01±0.47	2.28±0.25	0.000

Data are means ± SD, 𝑛 (%), or median (interquartile range).
T2D: type 2 diabetic group, Ctrl: control group, HADS-D: Depression Subscale of Hospital Anxiety and Depression Scale, BMI: body mass index, WHR: waist-to-hip ratio, FPG: fasting plasma glucose, FIN: fasting insulin, HOMA-IR: homeostasis model assessment-insulin resistance [HOMA-IR = FIN (mIU/L) × FPG (mmol/L)/22.5], 8-OHdG: Human 8-hydroxy-desoxyguanosine.
*The total score of HADS-D is 21 and depression was identified as the score ≥10.