Table of Contents Author Guidelines Submit a Manuscript
Oxidative Medicine and Cellular Longevity
Volume 2014 (2014), Article ID 681318, 9 pages
http://dx.doi.org/10.1155/2014/681318
Clinical Study

Intake of Red Wine in Different Meals Modulates Oxidized LDL Level, Oxidative and Inflammatory Gene Expression in Healthy People: A Randomized Crossover Trial

1Section of Clinical Nutrition and Nutrigenomic, Department of Biomedicine and Prevention, University of Rome Tor Vergata, Via Montpellier 1, 00136 Roma, Italy
2CNR, ISN UOS of Pharmacology, Department of Pharmacology, University Magna Graecia, Roccelletta di Borgia, 88021 Catanzaro, Italy
3National Institute for Mediterranean Diet and Nutrigenomics (I.N.Di.M.), Corso Vittorio Emanuele 4, 87032 Amantea, Italy

Received 14 February 2014; Revised 3 April 2014; Accepted 10 April 2014; Published 30 April 2014

Academic Editor: Kota V. Ramana

Copyright © 2014 Laura Di Renzo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. L. Di Renzo, A. Carraro, D. Minella et al., “Nutrient analysis critical control point (NACCP): hazelnut as a prototype of nutrigenomic study,” Food and Nutrition Sciences, vol. 5, pp. 79–88, 2014. View at Google Scholar
  2. E. R. Stadtman and B. S. Berlett, “Reactive oxygen-mediated protein oxidation in aging and disease,” Chemical Research in Toxicology, vol. 10, no. 5, pp. 485–494, 1997. View at Publisher · View at Google Scholar · View at Scopus
  3. R. Ross, “Atherosclerosis—an inflammatory disease,” The New England Journal of Medicine, vol. 340, no. 2, pp. 115–126, 1999. View at Publisher · View at Google Scholar · View at Scopus
  4. A. Fan, X. Wu, H. Wu et al., “Atheroprotective effect of oleoylethanolamide (OEA) targeting oxidazed LDL,” Plose ONE, vol. 9, no. 1, Article ID e85337, 2014. View at Publisher · View at Google Scholar
  5. H. Iatbe, T. Obama, and R. Kato, “The dynamics of oxidazed LDL during atherogenesis,” Journal of Lipids, vol. 2011, Article ID 418313, 9 pages, 2011. View at Publisher · View at Google Scholar
  6. M. I. Burgos Alves, F. Avilés Plaza, R. Martínez-Tomás et al., “Oxidized LDL and its correlation with lipid profile and oxidative stress biomarkers in young healthy Spanish subjects,” Journal of Physiology and Biochemistry, vol. 66, no. 3, pp. 221–227, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. S. Ehara, M. Ueda, T. Naruko et al., “Elevated levels of oxidized low density lipoprotein show a positive relationship with the severity of acute coronary syndromes,” Circulation, vol. 103, no. 15, pp. 1955–1960, 2001. View at Google Scholar · View at Scopus
  8. D. Ghosh and A. Scheepens, “Vascular action of polyphenols,” Molecular Nutrition and Food Research, vol. 53, no. 3, pp. 322–331, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. S. Kuriyama, T. Shimazu, K. Ohmori et al., “Green tea consumption and mortality due to cardiovascular disease, cancer, and all causes in Japan: the Ohsaki study,” Journal of the American Medical Association, vol. 296, no. 10, pp. 1255–1265, 2006. View at Publisher · View at Google Scholar · View at Scopus
  10. P. J. Mink, C. G. Scrafford, L. M. Barraj et al., “Flavonoid intake and cardiovascular disease mortality: a prospective study in postmenopausal women,” American Journal of Clinical Nutrition, vol. 85, no. 3, pp. 895–909, 2007. View at Google Scholar · View at Scopus
  11. P. E. Szmitko and S. Verma, “Cardiology patient pages. Red wine and your heart,” Circulation, vol. 111, no. 2, pp. e10–11, 2005. View at Google Scholar · View at Scopus
  12. V. Habauzit and C. Morand, “Evidence for a protective effect of polyphenols-containing foods on cardiovascular health: an update for clinicians,” Therapeutic Advances in Chronic Disease, vol. 3, no. 2, pp. 87–106, 2012. View at Publisher · View at Google Scholar · View at Scopus
  13. E. M. Holt, L. M. Steffen, A. Moran et al., “Fruit and vegetable consumption and its relation to markers of inflammation and oxidative stress in adolescents,” Journal of the American Dietetic Association, vol. 109, no. 3, pp. 414–421, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. A. De Lorenzo, A. Noce, M. Bigioni et al., “The effects of Italian Mediterranean organic diet (IMOD) on health status,” Current Pharmaceutical Design, vol. 16, no. 7, pp. 814–824, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. C. M. Kastorini, H. J. Milionis, K. Kalantzi et al., “The mediating effect of the Mediterranean diet on the role of discretionary and hidden salt intake regarding non-fatal acute coronary syndrome or stroke events: case/case-control study,” Atherosclerosis, vol. 225, no. 1, pp. 187–193, 2012. View at Google Scholar
  16. D. De Beer, E. Joubert, J. Marais, and M. Manley, “Unravelling the total antioxidant capacity of pinotage wines: contribution of phenolic compounds,” Journal of Agricultural and Food Chemistry, vol. 54, no. 8, pp. 2897–2905, 2006. View at Publisher · View at Google Scholar · View at Scopus
  17. M.-J. Oliveras-López, G. Berná, E. M. Carneiro, H. L.-G. De La Serrana, F. Martín, and M. C. López, “An extra-virgin olive oil rich in polyphenolic compounds has antioxidant effects in Of1 mice,” Journal of Nutrition, vol. 138, no. 6, pp. 1074–1078, 2008. View at Google Scholar · View at Scopus
  18. R. Rodrigo, G. Rivera, M. Orellana, J. Araya, and C. Bosco, “Rat kidney antioxidant response to long-term exposure to flavonol rich red wine,” Life Sciences, vol. 71, no. 24, pp. 2881–2895, 2002. View at Publisher · View at Google Scholar · View at Scopus
  19. R. Rodrigo, C. Bosco, P. Herrera, and G. Rivera, “Amelioration of myoglobinuric renal damage in rats by chronic exposure to flavonol-rich red wine,” Nephrology Dialysis Transplantation, vol. 19, no. 9, pp. 2237–2244, 2004. View at Publisher · View at Google Scholar · View at Scopus
  20. A. Girard, S. Madani, F. Boukortt, M. Cherkaoui-Malki, J. Belleville, and J. Prost, “Fructose-enriched diet modifies antioxidant status and lipid metabolism in spontaneously hypertensive rats,” Nutrition, vol. 22, no. 7-8, pp. 758–766, 2006. View at Publisher · View at Google Scholar · View at Scopus
  21. L. Di Renzo, F. Galvano, C. Orlandi et al., “Oxidative stress in normal-weight obese syndrome,” Obesity, vol. 18, no. 11, pp. 2125–2130, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. I. Grattagliano, V. O. Palmieri, P. Portincasa, A. Moschetta, and G. Palasciano, “Oxidative stress-induced risk factors associated with the metabolic syndrome: a unifying hypothesis,” Journal of Nutritional Biochemistry, vol. 19, no. 8, pp. 491–504, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. T. Werner, “Cluster analysis and promoter modelling as bioinformatics tools for the identification of target genes from expression array data,” Pharmacogenomics, vol. 2, no. 1, pp. 25–36, 2001. View at Publisher · View at Google Scholar · View at Scopus
  24. P. M. Murphy, M. Baggiolini, I. F. Charo et al., “International union of pharmacology. XXII. Nomenclature for chemokine receptors,” Pharmacological Reviews, vol. 52, no. 1, pp. 145–176, 2000. View at Google Scholar · View at Scopus
  25. H. Yamamoto, K. Schoonjans, and J. Auwerx, “Sirtuin functions in health and disease,” Molecular Endocrinology, vol. 21, no. 8, pp. 1745–1755, 2007. View at Publisher · View at Google Scholar · View at Scopus
  26. R. A. Frye, “Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins,” Biochemical and Biophysical Research Communications, vol. 273, no. 2, pp. 793–798, 2000. View at Publisher · View at Google Scholar · View at Scopus
  27. F. Wang, M. Nguyen, F. X.-F. Qin, and Q. Tong, “SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction,” Aging Cell, vol. 6, no. 4, pp. 505–514, 2007. View at Publisher · View at Google Scholar · View at Scopus
  28. T. G. Lohman, A. F. Roche, and R. Martorell, Anthropometric Standardization Reference Manual, Human Kinetics, Champaign, Ill, USA, 1998.
  29. L. Di Renzo, V. Del Gobbo, M. Bigioni, M. G. Premrov, R. Cianci, and A. De Lorenzo, “Body composition analyses in normal weight obese women,” European Review for Medical and Pharmacological Sciences, vol. 10, no. 4, pp. 191–196, 2006. View at Google Scholar · View at Scopus
  30. A. De Lorenzo, V. Del Gobbo, M. G. Premrov, M. Bigioni, F. Galvano, and L. Di Renzo, “Normal-weight obese syndrome: early inflammation?” American Journal of Clinical Nutrition, vol. 85, no. 1, pp. 40–45, 2007. View at Google Scholar · View at Scopus
  31. G. A. Mensah, A. H. Mokdad, E. Ford et al., “Obesity, metabolic syndrome, and type 2 diabetes: emerging epidemics and their cardiovascular implications,” Cardiology Clinics, vol. 22, no. 4, pp. 485–504, 2004. View at Publisher · View at Google Scholar · View at Scopus
  32. S. Wheatcroft, B. Noronha, and M. Kearney, “Heart and blood vessel,” in Clinical Nutrition, M. J. Gibney, M. Ela, and O. Ljunqvist, Eds., Blacwell Science, Oxford, UK edition, 2005. View at Google Scholar
  33. P. M. Kris-Etherton and C. L. Keen, “Evidence that the antioxidant flavonoids in tea and cocoa are beneficial for cardiovascular health,” Current Opinion in Lipidology, vol. 13, no. 1, pp. 41–49, 2002. View at Publisher · View at Google Scholar · View at Scopus
  34. G. Bjelakovic, D. Nikolova, L. L. Gluud, R. G. Simonetti, and C. Gluud, “Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis,” Journal of the American Medical Association, vol. 297, no. 8, pp. 842–857, 2007. View at Publisher · View at Google Scholar · View at Scopus
  35. D. P. Vivekananthan, M. S. Penn, S. K. Sapp, A. Hsu, and E. J. Topol, “Use of antioxidant vitamins for the prevention of cardiovascular disease: metaanalysis of randomised trials,” The Lancet, vol. 361, pp. 2017–2023, 2003. View at Google Scholar
  36. A. R. Collins, “Assays for oxidative stress and antioxidant status: applications to research into the biological effectiveness of polyphenols,” The American Journal of Clinical Nutrition, vol. 81, supplement 1, pp. 261S–267S, 2005. View at Google Scholar · View at Scopus
  37. D. Steinberg, S. Parthasarathy, T. E. Carew, J. C. Khoo, and J. L. Witztum, “Beyond cholesterol: modifications of low-density lipoprotein that increase its atherogenicity,” The New England Journal of Medicine, vol. 320, no. 14, pp. 915–924, 1989. View at Google Scholar · View at Scopus
  38. G. Fantuzzi and T. Mazzone, “Adipose tissue and atherosclerosis: exploring the connection,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 27, no. 5, pp. 996–1003, 2007. View at Publisher · View at Google Scholar · View at Scopus
  39. C. K. Glass and J. L. Witztum, “Atherosclerosis: the road ahead,” Cell, vol. 104, no. 4, pp. 503–516, 2001. View at Publisher · View at Google Scholar · View at Scopus
  40. K. Nishi, H. Itabe, M. Uno, and K. T. Kitazabo, “Oxidazed LDL in carotid plaques instability,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 22, pp. 1649–1654, 2002. View at Google Scholar
  41. S. Das, D. D. Santani, and N. S. Dhalla, “Experimental evidence for the cardioprotective effects of red wine,” Experimental and Clinical Cardiology, vol. 12, no. 1, pp. 5–10, 2007. View at Google Scholar · View at Scopus
  42. M. Taborsky, P. Ostadal, and M. Petrek, “A pilot randomized trial comparing long-term effects of red and white wine on biomarkers of atherosclerosis (In vino veritas: IVV trial),” Bratislavské Lekárske Listy, vol. 113, no. 3, pp. 156–158, 2012. View at Google Scholar
  43. H. K. Yildirim, Y. D. Akçay, U. Güvenç, and E. Y. Sözmen, “Protection capacity against low-density lipoprotein oxidation and antioxidant potential of some organic and non-organic wines,” International Journal of Food Sciences and Nutrition, vol. 55, no. 5, pp. 351–362, 2004. View at Publisher · View at Google Scholar · View at Scopus
  44. A. Jamroz and J. Bełtowski, “Antioxidant capacity of selected wines,” Medical Science Monitor, vol. 7, no. 6, pp. 1198–1202, 2001. View at Google Scholar · View at Scopus
  45. N. Landrault, P. Poucheret, P. Ravel, F. Gasc, G. Cros, and P.-L. Teissedre, “Antioxidant capacities and phenolics levels of French wines from different varieties and vintages,” Journal of Agricultural and Food Chemistry, vol. 49, no. 7, pp. 3341–3348, 2001. View at Publisher · View at Google Scholar · View at Scopus
  46. R. A. Kloner and S. H. Rezkalla, “To drink or not to drink? That is the question,” Circulation, vol. 116, no. 11, pp. 1306–1317, 2007. View at Publisher · View at Google Scholar · View at Scopus
  47. G. Avellone, V. Di Garbo, D. Campisi et al., “Effects of moderate Sicilian red wine consumption on inflammatory biomarkers of atherosclerosis,” European Journal of Clinical Nutrition, vol. 60, no. 1, pp. 41–47, 2006. View at Publisher · View at Google Scholar · View at Scopus
  48. S. R. Coimbra, S. H. Lage, L. Brandizzi, V. Yoshida, and P. L. da Luz, “The action of red wine and purple grape juice on vascular reactivity is independent of plasma lipids in hypercholesterolemic patients,” Brazilian Journal of Medical and Biological Research, vol. 38, no. 9, pp. 1339–1347, 2005. View at Google Scholar · View at Scopus
  49. M. Krenz and R. J. Korthuis, “Moderate ethanol ingestion and cardiovascular protection: from epidemiologic associations to cellular mechanisms,” Journal of Molecular and Cellular Cardiology, vol. 52, no. 1, pp. 93–104, 2012. View at Publisher · View at Google Scholar · View at Scopus
  50. J. H. O'Keefe, K. A. Bybee, and C. J. Lavie, “Alcohol and cardiovascular health: the razor-sharp double-edged sword,” Journal of the American College of Cardiology, vol. 50, no. 11, pp. 1009–1014, 2007. View at Publisher · View at Google Scholar · View at Scopus
  51. J. M. Smoliga, J. A. Baur, and H. A. Hausenblas, “Resveratrol and health—a comprehensive review of human clinical trials,” Molecular Nutrition and Food Research, vol. 55, no. 8, pp. 1129–1141, 2011. View at Publisher · View at Google Scholar · View at Scopus
  52. J. Tomé-Carneiro, M. Gonzálvez, M. Larrosa et al., “Consumption of a grape extract supplement containing resveratrol decreases oxidized LDL and ApoB in patients undergoing primary prevention of cardiovascular disease: a triple-blind, 6-month follow-up, placebo-controlled, randomized trial,” Molecular Nutrition & Food Research, vol. 56, pp. 810–821, 2012. View at Publisher · View at Google Scholar
  53. M. S. Fernández-Pachón, G. Berná, E. Otaolaurruchi, A. M. Troncoso, F. Martín, and M. C. García-Parrilla, “Changes in antioxidant endogenous enzymes (activity and gene expression levels) after repeated red wine intake,” Journal of Agricultural and Food Chemistry, vol. 57, no. 15, pp. 6578–6583, 2009. View at Publisher · View at Google Scholar · View at Scopus
  54. R. González, I. Ballester, R. López-Posadas et al., “Effects of flavonoids and other polyphenols on inflammation,” Critical Reviews in Food Science and Nutrition, vol. 51, no. 4, pp. 331–362, 2011. View at Publisher · View at Google Scholar · View at Scopus
  55. E. R. Stadtman and B. S. Berlett, “Reactive oxygen mediated protein oxidation in aging and disease,” Chemical Research in Toxicology, vol. 10, pp. 485–494, 1997. View at Google Scholar
  56. M. J. Kim, D. W. Kim, J. H. Park et al., “PEP-1-SIRT2 inhibits inflammatory response andoxidative stress-induced cell death via expression of antioxidant enzymes inmurinemacrophages,” Free Radical Biology and Medicine, vol. 63, pp. 432–445, 2013. View at Google Scholar
  57. Z. Ungvari, W. E. Sonntag, R. De Cabo, J. A. Baur, and A. Csiszar, “Mitochondrial protection by resveratrol,” Exercise and Sport Sciences Reviews, vol. 39, no. 3, pp. 128–132, 2011. View at Publisher · View at Google Scholar · View at Scopus
  58. M. Lagouge, C. Argmann, Z. Gerhart-Hines et al., “Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1α,” Cell, vol. 127, no. 6, pp. 1109–1122, 2006. View at Publisher · View at Google Scholar · View at Scopus
  59. H. Schirmer, T. C. B. Pereira, E. P. Rico et al., “Modulatory effect of resveratrol on SIRT1, SIRT3, SIRT4,PGC1α and NAMPT gene expression profiles in wild-type adult zebrafish liver,” Molecular Biology Reports, vol. 39, pp. 3281–3289, 2012. View at Publisher · View at Google Scholar · View at Scopus
  60. S. Mukherjee, I. Lekli, N. Gurusamy, A. A. A. Bertelli, and D. K. Das, “Expression of the longevity proteins by both red and white wines and their cardioprotective components, resveratrol, tyrosol, and hydroxytyrosol,” Free Radical Biology and Medicine, vol. 46, no. 5, pp. 573–578, 2009. View at Publisher · View at Google Scholar · View at Scopus
  61. Y.-L. Lin, C.-C. Liu, J.-I. Chuang et al., “Involvement of oxidative stress, NF-IL-6, and RANTES expression in dengue-2-virus-infected human liver cells,” Virology, vol. 276, no. 1, pp. 114–126, 2000. View at Publisher · View at Google Scholar · View at Scopus
  62. Y. Zheng, V. Le, Z. Cheng et al., “Development of rapid and highly sensitive HSPA1A promoter-driven luciferase reporter system for assessing oxidative stress associated with low-dose photodynamic therapy,” Cell Stress & Chaperones, vol. 18, no. 2, pp. 203–213, 2013. View at Publisher · View at Google Scholar
  63. R. S. Williams, H. F. Willard, and R. Snyderman, “Personalized health planning,” Science, vol. 300, no. 5619, p. 549, 2003. View at Publisher · View at Google Scholar · View at Scopus