Caenorhabditis elegans: A Useful Model for Studying Metabolic Disorders in Which Oxidative Stress Is a Contributing Factor

Figure 1

Machinery that protects against oxidative stress and intracellular ROS overproduction. The principal ROS include the superoxide anion (O₂^•−), hydrogen peroxide (H₂O₂), and the hydroxyl radical (HO^•). Cellular redox homeostasis is maintained by a set of antioxidant enzymes, such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and peroxiredoxin (Prx).