Review Article
Caenorhabditis elegans: A Useful Model for Studying Metabolic Disorders in Which Oxidative Stress Is a Contributing Factor
Table 1
A comparison of evolutionarily conserved antioxidant enzymes expressed in mammals and C. elegans.
| | Mammals | C. elegans | | Enzyme | Cellular localization | Ref. | Enzyme | Cellular localization | Ref. |
| | SOD1 (Cu/ZnSOD) | Cytosol
Mitochondria
Nucleus
Lysosomes | [29] | Cu/ZnSODs (sod-1 and sod-5) | Cytosol | [35–37, 42] | | SOD2 (MnSOD) | Mitochondria | [29] | MnSODs (sod-2 and sod-3) | Mitochondria | | SOD3 | Extracellular matrix | [29] | Predicted Cu/ZnSOD (sod-4) | Extracellular matrix |
| | Catalase | Cytosol
Peroxisomes |
[43] | ctl-1 | Cytosol | [44, 45] | | ctl-2, ctl-3 | Peroxisomes |
| | Peroxiredoxins (PrxI -VI) | Ubiquitous |
[46] | prdx-3 | Mitochondria | [47] | | prdx-2 | Intestine | [48] |
| | Glutathione peroxidase (GPx1-8) | Ubiquitous | [49] | gpx1-8 | Unknown | [50] |
| | Glutathione S-transferases (GSTs) | Cytosol
Mitochondria
Endoplasmic reticulum
Nucleus
Plasma membrane | [51] | Ce-GST-p24 (gst-4/K08F4.7), CeGSTP2-2 (gst-10) and GSTO-1 (C29E4.7) | Intestine
Muscle cells
Neurons | [52] |
|
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