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Oxidative Medicine and Cellular Longevity
Volume 2014 (2014), Article ID 720347, 9 pages
Research Article

Oxidative Stress Is Predominant in Female but Not in Male Patients with Autoimmune Thrombocytopenia

Institute for Transfusion Medicine, Charité University Medicine, Augustenburger Platz 1, 13353 Berlin, Germany

Received 23 September 2013; Accepted 10 December 2013; Published 6 January 2014

Academic Editor: Swaran J. S. Flora

Copyright © 2014 Julian Kamhieh-Milz and Abdulgabar Salama. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


As the involvement of oxidative stress (OS) in autoimmune thrombocytopenia (AITP) has been reported, a fast and rapid test for the reliable measurement of OS and antioxidant capacities (AOCs) might be a useful tool in extending current diagnostic possibilities. The free oxygen radical test (FORT) and free oxygen radical defence (FORD) assay (Callegari, Italy) are easy to perform and reliable, with results available within 15 minutes. Thirty-seven AITP patients and 37 matched healthy individuals were included in this study. All participants responded to a standard questionnaire provided by these assays. Female patients with AITP were observed to demonstrate significantly higher OS in comparison to female controls ( ) and male AITP patients ( ). The AOCs were not reduced in patients with AITP ( ). Correlation of OS with platelet count identified a weak positive correlation ( , Spearman ). The questionnaire revealed that ITP patients in comparison to healthy controls are more stressed, feel exhausted and fatigued, and eat a healthier diet. In conclusion, OS is predominant in female but not in male patients with AITP suggesting gender-specific differences in the pathomechanisms of AITP. Identification of patients with high levels of OS might be beneficial in the management of AITP.