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Oxidative Medicine and Cellular Longevity
Volume 2014, Article ID 721043, 10 pages
http://dx.doi.org/10.1155/2014/721043
Review Article

Antioxidant Strategies and Respiratory Disease of the Preterm Newborn: An Update

1Neonatal Intensive Care Unit, Careggi University Hospital, 3 Largo Brambilla, 50141 Florence, Italy
2Section of Neonatology, Department of Neurosciences, Psychology, Drug Research and Child Health, Careggi University Hospital, 3 Largo Brambilla, 50141 Florence, Italy

Received 10 January 2014; Accepted 6 March 2014; Published 7 April 2014

Academic Editor: Serafina Perrone

Copyright © 2014 Chiara Poggi and Carlo Dani. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. O. D. Saugstad, “Oxidative stress in the newborn-a 30-year perspective,” Biology of the Neonate, vol. 88, no. 3, pp. 228–236, 2005. View at Publisher · View at Google Scholar · View at Scopus
  2. G. Buonocore, S. Perrone, and M. L. Tataranno, “Oxygen toxicity: chemistry and biology of reactive oxygen species,” Seminars in Fetal and Neonatal Medicine, vol. 15, no. 4, pp. 186–190, 2010. View at Publisher · View at Google Scholar · View at Scopus
  3. J. P. Kinsella, A. Greenough, and S. H. Abman, “Bronchopulmonary dysplasia,” The Lancet, vol. 367, no. 9520, pp. 1421–1431, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. S. Perrone, M. L. Tataranno, S. Negro et al., “Early identification of the risk for free radical-related diseases in preterm newborns,” Early Human Development, vol. 86, no. 4, pp. 241–244, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. S. Perrone, S. Negro, M. L. Tataranno, and G. Buonocore, “Oxidative stress and antioxidant strategies in newborns,” Journal of Maternal-Fetal and Neonatal Medicine, vol. 23, no. 3, pp. 63–65, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. M. Vento, M. Moro, R. Escrig et al., “Preterm resuscitation with low oxygen causes less oxidative stress, inflammation, and chronic lung disease,” Pediatrics, vol. 124, no. 3, pp. e439–e449, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. O. D. Saugstad, S. Ramji, R. F. Soll, and M. Vento, “Resuscitation of newborn infants with 21% or 100% oxygen: an updated systematic review and meta-analysis,” Neonatology, vol. 94, no. 3, pp. 176–182, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. J. M. Perlman, J. Wyllie, J. Kattwinkel et al., “Neonatal resuscitation chapter collaborators. Part 11: Neonatal resuscitation: 2010 International consensus on cardiopulmonary resuscitation and emergency cardiovascular care science with treatment recommendations,” Circulation, vol. 122, supplement 16, pp. S516–S538, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. M. Vento, J. Escobar, M. Cernada, R. Escrig, and M. Aguar, “The use and misuse of oxygen during the neonatal period,” Clinics in Perinatology, vol. 39, no. 1, pp. 165–176, 2012. View at Publisher · View at Google Scholar · View at Scopus
  10. J. A. Dawson, C. O. F. Kamlin, M. Vento et al., “Defining the reference range for oxygen saturation for infants after birth,” Pediatrics, vol. 125, no. 6, pp. e1340–e1347, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. M. Vento, E. Cubells, J. J. Escobar et al., “Oxygen saturation after birth in preterm infants treated with continuous positive airway pressure and air: assessment of gender differences and comparison with a published nomogram,” Archives of Disease in Childhood. Fetal and Neonatal Edition, vol. 98, no. 3, pp. F228–F232, 2013. View at Publisher · View at Google Scholar
  12. J. A. Dawson, M. Vento, N. N. Finer et al., “Managing oxygen therapy during delivery room stabilization of preterm infants,” Journal of Pediatrics, vol. 160, no. 1, pp. 158–161, 2012. View at Publisher · View at Google Scholar · View at Scopus
  13. J. J. Coalson, “Pathology of new bronchopulmonary dysplasia,” Seminars in Neonatology, vol. 8, no. 1, pp. 73–81, 2003. View at Publisher · View at Google Scholar · View at Scopus
  14. E. Gitto, S. Pellegrino, S. D'Arrigo, I. Barberi, and R. J. Reiter, “Oxidative stress in resuscitation and in ventilation of newborns,” European Respiratory Journal, vol. 34, no. 6, pp. 1461–1469, 2009. View at Publisher · View at Google Scholar · View at Scopus
  15. L. Frank and I. R. Sosenko, “Failure of premature rabbits to increase antioxidant enzymes during hyperoxic exposure: increased susceptibility to pulmonary oxygen toxicity compared with term rabbits,” Pediatric Research, vol. 29, no. 3, pp. 292–296, 1991. View at Google Scholar · View at Scopus
  16. R. L. Morton, K. C. Das, X. Guo, D. N. Iklé, and C. W. White, “Effect of oxygen on lung superoxide dismutase activities in premature baboons with bronchopulmonary dysplasia,” American Journal of Physiology-Lung Cellular and Molecular Physiology, vol. 276, no. 1, pp. L64–L74, 1999. View at Google Scholar · View at Scopus
  17. S. Lurie, Z. Matas, M. Boaz, A. Fux, A. Golan, and O. Sadan, “Different degrees of fetal oxidative stress in elective and emergent cesarean section,” Neonatology, vol. 92, no. 2, pp. 111–115, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. M. Vento, M. Asensi, J. Sastre, A. Lloret, F. García-Sala, and J. Viña, “Oxidative stress in asphyxiated term infants resuscitated with 100% oxygen,” Journal of Pediatrics, vol. 142, no. 3, pp. 240–246, 2003. View at Publisher · View at Google Scholar · View at Scopus
  19. A. Kumar, S. V. K. Ramakrishna, S. Basu, and G. R. K. Rao, “Oxidative stress in perinatal asphyxia,” Pediatric Neurology, vol. 38, no. 3, pp. 181–185, 2008. View at Publisher · View at Google Scholar · View at Scopus
  20. F. Stigger, G. Lovatel, M. Marques et al., “Inflammatory response and oxidative stress in developing rat brain and its consequences on motor behavior following maternal administration of LPS and perinatal anoxia,” International Journal of Developmental Neuroscience, vol. 31, no. 8, pp. 820–827, 2013. View at Publisher · View at Google Scholar
  21. F. Capani, C. F. Loidl, F. Aguirre et al., “Changes in reactive oxygen species (ROS) production in rat brain during global perinatal asphyxia: an ESR study,” Brain Research, vol. 914, no. 1-2, pp. 204–207, 2001. View at Publisher · View at Google Scholar · View at Scopus
  22. L. Ciccoli, V. Rossi, S. Leoncini et al., “Iron release in erythrocytes and plasma non protein-bound iron in hypoxic and non hypoxic newborns,” Free Radical Research, vol. 37, no. 1, pp. 51–58, 2003. View at Publisher · View at Google Scholar · View at Scopus
  23. L. Ciccoli, V. Rossi, S. Leoncini et al., “Iron release, superoxide production and binding of autologous IgG to band 3 dimers in newborn and adult erythrocytes exposed to hypoxia and hypoxia-reoxygenation,” Biochimica et Biophysica Acta-General Subjects, vol. 1672, no. 3, pp. 203–213, 2004. View at Publisher · View at Google Scholar · View at Scopus
  24. B. Marzocchi, L. Ciccoli, C. Tani et al., “Hypoxia-induced post-translational changes in red blood cell protein map of newborns,” Pediatric Research, vol. 58, no. 4, pp. 660–665, 2005. View at Publisher · View at Google Scholar · View at Scopus
  25. S. Perrone, M. L. Tataranno, G. Stazzoni, A. Del Vecchio, and G. Buonocore, “Oxidative injury in neonatal erythrocytes,” Journal of Maternal-Fetal and Neonatal Medicine, vol. 25, supplement 5, pp. 104–108, 2012. View at Google Scholar
  26. R. S. Gill, T. F. Lee, N. Manouchehri et al., “Postresuscitation cyclosporine treatment attenuates myocardial and cardiac mitochondrial injury in newborn piglets with asphyxia-reoxygenation,” Critical Care Medicine, vol. 41, no. 4, pp. 1069–1074, 2013. View at Google Scholar
  27. J. R. Labossiere, J. S. Pelletier, M. A. Ali et al., “Postresuscitation administration of doxycycline preserves cardiac contractile function in hypoxia-reoxygenation injury of newborn piglets,” Critical Care Medicine, 2013. View at Google Scholar
  28. P. Y. Cheung, M. Miedzyblocki, T. F. Lee, and D. L. Bigam , “Effects of post-resuscitation administration with sodium hydrosulfide on cardiac recovery in hypoxia-reoxygenated newborn piglets,” European Journal of Pharmacology, vol. 718, no. 1–3, pp. 74–80, 2013. View at Publisher · View at Google Scholar
  29. Z. Wang, H. Zhao, S. Peng, and Z. Zuo, “Intranasal pyrrolidine dithiocarbamate decreases brain inflammatory mediators and provides neuroprotection after brain hypoxia-ischemia in neonatal rats,” Experimental Neurology, vol. 249, pp. 74–82, 2013. View at Publisher · View at Google Scholar
  30. R. S. Gill, T. F. Lee, J. Q. Liu et al., “Cyclosporine treatment reduces oxygen free radical generation and oxidative stress in the brain of hypoxia-reoxygenated newborn piglets,” PLoS ONE, vol. 7, Article ID e40471, 2012. View at Google Scholar
  31. J. L. Slaughter, M. R. Stenger, and P. B. Reagan, “Variation in the use of diuretic therapy for infants with bronchopulmonary dysplasia,” Pediatrics, vol. 131, no. 4, pp. 716–723, 2013. View at Publisher · View at Google Scholar
  32. C. Rodriguez, J. C. Mayo, R. M. Sainz et al., “Regulation of antioxidant enzymes: a significant role for melatonin,” Journal of Pineal Research, vol. 36, no. 1, pp. 1–9, 2004. View at Publisher · View at Google Scholar · View at Scopus
  33. D. X. Tan, L. C. Manchester, M. P. Terron, L. J. Flores, and R. J. Reiter, “One molecule, many derivatives: a never-ending interaction of melatonin with reactive oxygen and nitrogen species?” Journal of Pineal Research, vol. 42, no. 1, pp. 28–42, 2007. View at Publisher · View at Google Scholar · View at Scopus
  34. N. J. Robertson, S. Faulkner, B. Fleiss et al., “Melatonin augments hypothermic neuroprotection in a perinatal asphyxia model,” Brain, vol. 136, no. 1, pp. 90–105, 2013. View at Publisher · View at Google Scholar
  35. E. Gitto, R. J. Reiter, S. P. Cordaro et al., “Oxidative and inflammatory parameters in respiratory distress syndrome of preterm newborns: beneficial effects of melatonin,” American Journal of Perinatology, vol. 21, no. 4, pp. 209–216, 2004. View at Publisher · View at Google Scholar · View at Scopus
  36. E. Gitto, R. J. Reiter, A. Amodio et al., “Early indicators of chronic lung disease in preterm infants with respiratory distress syndrome and their inhibition by melatonin,” Journal of Pineal Research, vol. 36, no. 4, pp. 250–255, 2004. View at Publisher · View at Google Scholar · View at Scopus
  37. E. Gitto, M. Karbownik, R. J. Reiter et al., “Effects of melatonin treatment in septic newborns,” Pediatric Research, vol. 50, no. 6, pp. 756–760, 2001. View at Google Scholar · View at Scopus
  38. L. Pan, J. Fu, X. Xue, W. Xu, P. Zhou, and B. Wei, “Melatonin protects against oxidative damage in a neonatal rat model of bronchopulmonary dysplasia,” World Journal of Pediatrics, vol. 5, no. 3, pp. 216–221, 2009. View at Publisher · View at Google Scholar · View at Scopus
  39. W. N. Rosenfeld, J. M. Davis, L. Parton et al., “Safety and pharmacokinetics of recombinant human superoxide dismutase administered intratracheally to premature neonates with respiratory distress syndrome,” Pediatrics, vol. 97, no. 6, pp. 811–817, 1996. View at Google Scholar · View at Scopus
  40. J. M. Davis, W. N. Rosenfeld, S. E. Richter et al., “Safety and pharmacokinetics of multiple doses of recombinant human CuZn superoxide dismutase administered intratracheally to premature neonates with respiratory distress syndrome,” Pediatrics, vol. 100, no. 1, pp. 24–30, 1997. View at Publisher · View at Google Scholar · View at Scopus
  41. J. M. Davis, S. E. Richter, S. Biswas et al., “Long-term follow-up of premature infants treated with prophylactic, intratracheal recombinant human CuZn superoxide dismutase,” Journal of Perinatology, vol. 20, no. 4, pp. 213–216, 2000. View at Google Scholar · View at Scopus
  42. J. M. Davis, R. B. Parad, T. Michele, E. Allred, A. Price, and W. Rosenfeld, “Pulmonary outcome at 1 year corrected age in premature infants treated at birth with recombinant human CuZn superoxide dismutase,” Pediatrics, vol. 111, no. 3, pp. 469–476, 2003. View at Publisher · View at Google Scholar · View at Scopus
  43. C. Dani and C. Poggi, “The role of genetic polymorphisms of antioxidant enzymes and potential antioxidant therapies in neonatal lung disease,” Antioxidants & Redox Signaling, 2014. View at Google Scholar
  44. J. F. Turrens, J. D. Crapo, and B. A. Freeman, “Protection against oxygen toxicity by intravenous injection of liposome-entrapped catalase and superoxide dismutase,” Journal of Clinical Investigation, vol. 73, no. 1, pp. 87–95, 1984. View at Google Scholar · View at Scopus
  45. R. V. Padmanabhan, R. Gudapaty, and I. E. Liener, “Protection against pulmonary oxygen toxicity in rats by the intratracheal administration of liposome-encapsulated superoxide dismutase or catalase,” American Review of Respiratory Disease, vol. 132, no. 1, pp. 164–167, 1985. View at Google Scholar · View at Scopus
  46. J. M. Davis, W. N. Rosenfeld, R. J. Sanders, and A. Gonenne, “Prophylactic effects of recombinant human superoxide dismutase in neonatal lung injury,” Journal of Applied Physiology, vol. 74, no. 5, pp. 2234–2241, 1993. View at Google Scholar · View at Scopus
  47. M. L. Barnard, R. R. Baker, and S. Matalon, “Mitigation of oxidant injury to lung microvasculature by intratracheal instillation of antioxidant enzymes,” American Journal of Physiology-Lung Cellular and Molecular Physiology, vol. 265, no. 4, pp. L340–L345, 1993. View at Google Scholar · View at Scopus
  48. M. N. Ahmed, H. B. Suliman, R. J. Folz et al., “Extracellular superoxide dismutase protects lung development in hyperoxia-exposed newborn mice,” American Journal of Respiratory and Critical Care Medicine, vol. 167, no. 3, pp. 400–405, 2003. View at Publisher · View at Google Scholar · View at Scopus
  49. R. L. Auten, M. A. O'Reilly, T. D. Oury, E. Nozik-Grayck, and M. H. Whorton, “Transgenic extracellular superoxide dismutase protects postnatal alveolar epithelial proliferation and development during hyperoxia,” American Journal of Physiology-Lung Cellular and Molecular Physiology, vol. 290, no. 1, pp. L32–L40, 2006. View at Publisher · View at Google Scholar · View at Scopus
  50. M. N. Ahmed, C. Codipilly, N. Hogg, and R. L. Auten, “The protective effect of overexpression of extracellular superoxide dismutase on nitric oxide bioavailability in the lung after exposure to hyperoxia stress,” Experimental Lung Research, vol. 37, no. 1, pp. 10–17, 2011. View at Publisher · View at Google Scholar · View at Scopus
  51. J. H. Min, C. N. Codipilly, S. Nasim, E. J. Miller, and M. N. Ahmed, “Synergistic protection against hyperoxia-induced lung injury by neutrophils blockade and EC-SOD overexpression,” Respiratory Research, vol. 13, p. 58, 2012. View at Publisher · View at Google Scholar
  52. L. M. Carlsson, J. Jonsson, T. Edlund, and S. L. Marklund, “Mice lacking extracellular superoxide dismutase are more sensitive to hyperoxia,” Proceedings of the National Academy of Sciences of the United States of America, vol. 92, no. 14, pp. 6264–6268, 1995. View at Publisher · View at Google Scholar · View at Scopus
  53. J. R. Wispe, B. B. Warner, J. C. Clark et al., “Human Mn-superoxide dismutase in pulmonary epithelial cells of transgenic mice confers protection from oxygen injury,” Journal of Biological Chemistry, vol. 267, no. 33, pp. 23937–23941, 1992. View at Google Scholar · View at Scopus
  54. R. J. Folz, A. M. Abushamaa, and H. B. Suliman, “Extracellular superoxide dismutase in the airways of transgenic mice reduces inflammation and attenuates lung toxicity following hyperoxia,” Journal of Clinical Investigation, vol. 103, no. 7, pp. 1055–1066, 1999. View at Google Scholar · View at Scopus
  55. D. Holst and Y. Garnier, “Preterm birth and inflammation-The role of genetic polymorphisms,” European Journal of Obstetrics Gynecology and Reproductive Biology, vol. 141, no. 1, pp. 3–9, 2008. View at Publisher · View at Google Scholar · View at Scopus
  56. C. Poggi, B. Giusti, A. Vestrini, E. Pasquini, R. Abbate, and C. Dani, “Genetic polymorphisms of antioxidant enzymes in preterm infants,” Journal of Maternal-Fetal and Neonatal Medicine, vol. 25, supplement 4, pp. 131–134, 2012. View at Google Scholar
  57. B. Giusti, A. Vestrini, C. Poggi et al., “Genetic polymorphisms of antioxidant enzymes as risk factors for oxidative stress-associated complications in preterm infants,” Free Radical Research, vol. 46, no. 9, pp. 1130–1139, 2012. View at Publisher · View at Google Scholar
  58. M. S. Esplin, “Preterm birth: a review of genetic factors and future directions for genetic study,” Obstetrical and Gynecological Survey, vol. 61, no. 12, pp. 800–806, 2006. View at Publisher · View at Google Scholar · View at Scopus
  59. T. Usuda, T. Kobayashi, S. Sakakibara et al., “Interleukin-6 polymorphism and bronchopulmonary dysplasia risk in very low-birthweight infants,” Pediatrics International, vol. 54, no. 4, pp. 471–475, 2012. View at Publisher · View at Google Scholar
  60. G. Bokodi, L. Derzbach, I. Bányász, T. Tulassay, and B. Vásárhelyi, “Association of interferon γ T+874A and interleukin 12 p40 promoter CTCTAA/GC polymorphism with the need for respiratory support and perinatal complications in low birthweight neonates,” Archives of Disease in Childhood: Fetal and Neonatal Edition, vol. 92, no. 1, pp. F25–F29, 2007. View at Publisher · View at Google Scholar · View at Scopus
  61. V. Sampath, J. S. Garland, M. Le et al., “A TLR5 (g.1174C > T) variant that encodes a stop codon (R392X) is associated with bronchopulmonary dysplasia,” Pediatric Pulmonology, vol. 47, no. 5, pp. 460–468, 2012. View at Publisher · View at Google Scholar · View at Scopus
  62. L. Derzbach, G. Bokodi, A. Treszl, B. Vásárhelyi, A. Nobilis, and J. Rigó Jr., “Selectin polymorphisms and perinatal morbidity in low-birthweight infants,” Acta Paediatrica, International Journal of Paediatrics, vol. 95, no. 10, pp. 1213–1217, 2006. View at Publisher · View at Google Scholar · View at Scopus
  63. G. Prencipe, C. Auriti, R. Inglese et al., “A polymorphism in the macrophage migration inhibitory factor promoter is associated with bronchopulmonary dysplasia,” Pediatric Research, vol. 69, no. 2, pp. 142–147, 2011. View at Publisher · View at Google Scholar · View at Scopus
  64. A. Hadchouel, F. Decobert, M. Franco-Montoya et al., “Matrix metalloproteinase gene polymorphisms and bronchopulmonary dysplasia: identification of MMP16 as a new player in lung development,” PLoS ONE, vol. 3, no. 9, Article ID e3188, 2008. View at Publisher · View at Google Scholar · View at Scopus
  65. S. S. Strassberg, I. A. Cristea, D. Qian, and L. A. Parton, “Single nucleotide polymorphisms of tumor necrosis factor-α and the susceptibility to bronchopulmonary dysplasia,” Pediatric Pulmonology, vol. 42, no. 1, pp. 29–36, 2007. View at Publisher · View at Google Scholar · View at Scopus
  66. M. H. Manar, M. R. Brown, T. W. Gauthier, and L. A. S. Brown, “Association of glutathione-S-transferase-P1 (GST-P1) polymorphisms with bronchopulmonary dysplasia,” Journal of Perinatology, vol. 24, no. 1, pp. 30–35, 2004. View at Publisher · View at Google Scholar · View at Scopus
  67. R. Ramanathan, “Choosing a right surfactant for respiratory distress syndrome treatment,” Neonatology, vol. 95, no. 1, pp. 1–5, 2008. View at Publisher · View at Google Scholar · View at Scopus
  68. C. Dani, G. Buonocore, M. Longini et al., “Superoxide dismutase and catalase activity in naturally derived commercial surfactants,” Pediatric Pulmonology, vol. 44, no. 11, pp. 1125–1131, 2009. View at Publisher · View at Google Scholar · View at Scopus
  69. S. Matalon and J. R. Wright, “Surfactant proteins and inflammation: the Yin and the Yang,” American Journal of Respiratory Cell and Molecular Biology, vol. 31, no. 6, pp. 585–586, 2004. View at Publisher · View at Google Scholar · View at Scopus
  70. S. Matalon, B. A. Holm, R. R. Baker, M. K. Whitfield, and B. A. Freeman, “Characterization of antioxidant activities of pulmonary surfactant mixtures,” Biochimica et Biophysica Acta-General Subjects, vol. 1035, no. 2, pp. 121–127, 1990. View at Publisher · View at Google Scholar · View at Scopus
  71. T. A. Merritt, M. Hallman, and K. Holcomb, “Human surfactant treatment of severe respiratory distress syndrome: pulmonary effluent indicators of lung inflammation,” Journal of Pediatrics, vol. 108, no. 5, pp. 741–748, 1986. View at Google Scholar · View at Scopus
  72. B. Nieves-Cruz, A. Rivera, J. Cifuentes et al., “Clinical surfactant preparations mediate SOD and catalase uptake by type II cells and lung tissue,” American Journal of Physiology-Lung Cellular and Molecular Physiology, vol. 270, no. 4, pp. L659–L667, 1996. View at Google Scholar · View at Scopus
  73. F. J. Walther, R. David-Cu, and S. L. Lopez, “Antioxidant-surfactant liposomes mitigate hyperoxic lung injury in premature rabbits,” American Journal of Physiology-Lung Cellular and Molecular Physiology, vol. 269, no. 5, pp. L613–L617, 1995. View at Google Scholar · View at Scopus
  74. M. Rüdiger, A. Tölle, W. Meier, and B. Rüstow, “Naturally derived commercial surfactants differ in composition of surfactant lipids and in surface viscosity,” American Journal of Physiology-Lung Cellular and Molecular Physiology, vol. 288, pp. L379–L383, 2005. View at Google Scholar
  75. R. A. Zoeller, O. H. Morand, and C. R. H. Raetz, “A possible role for plasmalogens in protecting animal cells against photosensitized killing,” Journal of Biological Chemistry, vol. 263, no. 23, pp. 11590–11596, 1988. View at Google Scholar · View at Scopus
  76. G. Jürgens, A. Fell, G. Ledinski, Q. Chen, and F. Paltauf, “Delay of copper-catalyzed oxidation of low density lipoprotein by in vitro enrichment with choline or ethanolamine plasmalogens,” Chemistry and Physics of Lipids, vol. 77, no. 1, pp. 25–31, 1995. View at Publisher · View at Google Scholar · View at Scopus
  77. M. Rüdiger, A. Von Baehr, R. Haupt, R. R. Wauer, and B. Rüstow, “Preterm infants with high polyunsaturated fatty acid and plasmalogen content in tracheal aspirates develop bronchopulmonary dysplasia less often,” Critical Care Medicine, vol. 28, no. 5, pp. 1572–1577, 2000. View at Google Scholar · View at Scopus
  78. H. P. Haagsman, A. Hogenkamp, M. Van Eijk, and E. J. A. Veldhuizen, “Surfactant collectins and innate immunity,” Neonatology, vol. 93, no. 4, pp. 288–294, 2008. View at Publisher · View at Google Scholar · View at Scopus
  79. S. Matalon, K. Shrestha, M. Kirk et al., “Modification of surfactant protein D by reactive oxygen-nitrogen intermediates is accompanied by loss of aggregating activity, in vitro and in vivo,” FASEB Journal, vol. 23, no. 5, pp. 1415–1430, 2009. View at Publisher · View at Google Scholar · View at Scopus
  80. Y. Wu, S. Adam, L. Hamann et al., “Accumulation of inhibitory κB-α as a mechanism contributing to the anti-inflammatory effects of surfactant protein-A,” American Journal of Respiratory Cell and Molecular Biology, vol. 31, no. 6, pp. 587–594, 2004. View at Publisher · View at Google Scholar · View at Scopus
  81. S. Kotecha, P. L. Davies, H. W. Clark, and E. P. McGreal, “Increased prevalence of low oligomeric state surfactant protein D with restricted lectin activity in bronchoalveolar lavage fluid from preterm infants,” Thorax, vol. 68, no. 5, pp. 460–467, 2013. View at Publisher · View at Google Scholar
  82. K. K. Ryckman, J. M. Dagle, K. Kelsey, A. M. Momany, and J. C. Murray, “Genetic associations of surfactant protein D and angiotensin-converting enzyme with lung disease in preterm neonates,” Journal of Perinatology, vol. 32, no. 5, pp. 349–355, 2012. View at Publisher · View at Google Scholar · View at Scopus