Expression of Senescence-Associated microRNAs and Target Genes in Cellular Aging and Modulation by Tocotrienol-Rich Fraction
Figure 1
Morphological changes and SA-β-gal staining of young HDFs (magnification 40x) (a), young HDFs (magnification 100x) (b), senescent HDFs (magnification 40x) (c), and senescent HDFs (magnification 100x) (d). Senescent HDFs showed morphological changes during replicative senescence with the loss of original fibroblastic shape, appearance of flattened morphology, and increased in the size of cells and nucleus. Only senescent HDFs showed positive SA-β-gal staining in blue as indicated by arrow.
