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Oxidative Medicine and Cellular Longevity
Volume 2014 (2014), Article ID 738679, 8 pages
http://dx.doi.org/10.1155/2014/738679
Research Article

Approach to Reduction of Blood Atherogenicity

1Institute for Atherosclerosis Research, Skolkovo Innovation Center, P.O. Box No. 21, Moscow 121609, Russia
2Institute of General Pathology and Pathophysiology, Baltiyskaya Street 8, Moscow 125315, Russia
3Russian Cardiology Research and Production Center, 3rd Cherepkovskaya Street 15a, Moscow 121552, Russia

Received 14 March 2014; Revised 15 May 2014; Accepted 9 June 2014; Published 29 June 2014

Academic Editor: Carlos Caulin

Copyright © 2014 Alexander N. Orekhov et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We have earlier found that blood sera of patients with coronary heart disease (CHD) increase lipid levels in cells cultured from subendothelial intima of human aorta. We have also revealed that the ability of blood sera to raise intracellular cholesterol; that is, their atherogenicity is caused by at least modified low density lipoprotein (LDL) circulating in the blood of patients and autoantibodies to modified LDL. In the present work we have demonstrated significant impact of nonlipid factor(s) to blood atherogenicity. We have developed an approach to removal of nonlipid atherogenicity factor(s) from blood serum based on the use of immobilized LDL. This approach was used for extracorporeal perfusion of patient’s blood through the column with immobilized LDL. Pilot clinical study confirmed the efficacy of this approach for prevention of coronary atherosclerosis progression.