[Retracted] PKCδ Promotes High Glucose Induced Renal Tubular Oxidative Damage via Regulating Activation and Translocation of p66Shc

Figure 5

PKCδ siRNA inhibits HG-induced p66Shc phosphorylation in HK-2 cells. HK-2 cells were transfected with either PKCδ siRNA or scrambled siRNA and then stimulated with 30 mM HG for 24 hrs. PKCδ, p66Shc, and p-p66Shc were detected by Western blot analysis. An increased expression of p-p66Shc was observed in HK-2 cells induced by HG, but it failed in the group treated with PKCδ siRNA. Values are means ± SEM, . versus LG group, versus scrambled siRNA.

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