Mitochondrial dysfunction induced by Aβ. In AD brain some areas are more sensitive to mitochondrial dysfunction. In the neurons Aβ induces mitochondrial dysfunction by using different mechanisms. Aβ is taken up by mitochondria via the TOM complex and imported in the inner membrane; Aβ alters the enzyme activity of the respiratory chain complexes I, II, and IV; Aβ affects mitochondrial dynamics by impaired balance of fission and fusion; Aβ causes formation of mPTP via interaction with CypD; Aβ induces decreased mitochondrial respiration; Aβ affects new mitochondrial biogenesis; Aβ increases ROS generation.