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Oxidative Medicine and Cellular Longevity
Volume 2014, Article ID 798957, 6 pages
Clinical Study

Ubiquinol Improves Symptoms in Children with Autism

1Pharmacobiochemical Laboratory of 3rd Medical Department, Medical Faculty, Comenius University in Bratislava, Sasinkova 4, 811 08 Bratislava, Slovakia
2Institute of Physiology, Medical Faculty, Comenius University in Bratislava, Sasinkova 4, 811 08 Bratislava, Slovakia
3Department of Biological Science, Purdue University, W. Lafayette, IN 47901, USA

Received 22 May 2013; Revised 16 January 2014; Accepted 16 January 2014; Published 23 February 2014

Academic Editor: Swaran J. S. Flora

Copyright © 2014 Anna Gvozdjáková et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Autism is a spectrum of neurodevelopmental disorders with manifestation within 3 years after birth. Manifestations of autism include behavior problems (hyperactivity, toys destruction, self-harm, and agression) and sleep and eating disorders. Etiology of autism is poorly understood. Oxidative stress and antioxidants can participate in pathobiochemical mechanisms of autism. Methods. Twenty-four children, aged 3–6 years, with autism according to the DSM IV criteria and using CARS were included in the study. Concentrations of , γ- and α-tocopherol, β-carotene, and lipid peroxidation were determined in plasma before and after three months of supportive therapy with ubiquinol at a daily dose  mg. Data on behavior of the children were collected from parents at the same time. Results. Ubiquinol supportive therapy improved symptoms in children with autism, as communication with parents (in ), verbal communication (in ), playing games of children (in ), sleeping (in ), and food rejection (in ), with plasma level above . Conclusions. Beneficial effect of ubiquinol in children with autism has been demonstrated for the first time. We assume that plasma concentration of and lipid peroxidation could be used as relevant biomarkers of ubiquinol supportive therapy.