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Oxidative Medicine and Cellular Longevity
Volume 2014 (2014), Article ID 824756, 8 pages
http://dx.doi.org/10.1155/2014/824756
Research Article

Lipid Peroxidation, Nitric Oxide Metabolites, and Their Ratio in a Group of Subjects with Metabolic Syndrome

Dipartimento Biomedico di Medicina Interna e Specialistica, Università di Palermo, Via del Vespro 129, 90100 Palermo, Italy

Received 31 March 2014; Revised 13 May 2014; Accepted 17 May 2014; Published 2 June 2014

Academic Editor: Vladimir Jakovljevic

Copyright © 2014 Gregorio Caimi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. L. A. Simons, J. Simons, Y. Friedlander, and J. McCallum, “Is prediction of cardiovascular disease and al-cause mortality genuinely driven by the metabolic syndrome, and independently from its component variables? The Dubbo Study,” Heart Lung and Circulation, vol. 20, no. 4, pp. 214–219, 2011. View at Publisher · View at Google Scholar · View at Scopus
  2. E. Hopps, D. Noto, G. Caimi, and M. R. Averna, “A novel component of the metabolic syndrome: the oxidative stress,” Nutrition, Metabolism and Cardiovascular Diseases, vol. 20, no. 1, pp. 72–77, 2010. View at Publisher · View at Google Scholar · View at Scopus
  3. N. Demircan, A. Gürel, F. Armutcu, M. Ünalacak, E. Aktunç, and H. Atmaca, “The evaluation of serum cystatin C, malondialdehyde, and total antioxidant status in patients with metabolic syndrome,” Medical Science Monitor, vol. 14, no. 2, pp. CR97–CR101, 2008. View at Google Scholar · View at Scopus
  4. J. Barona, J. J. Jonesa, R. E. Kopecc et al., “A Mediterranean-style low-glycemic-load diet increases plasma carotenoids and decreases LDL oxidation in women with metabolic syndrome,” Journal of Nutritional Biochemistry, vol. 23, pp. 609–615, 2012. View at Publisher · View at Google Scholar
  5. J. L. Jones, M. Comperatore, J. Barona et al., “A Mediterranean-style, low-glycemic-load diet decreases atherogenic lipoproteins and reduces lipoprotein (a) and oxidized low-density lipoprotein in women with metabolic syndrome,” Metabolism: Clinical and Experimental, vol. 61, no. 3, pp. 366–372, 2012. View at Publisher · View at Google Scholar · View at Scopus
  6. M. Kim, J. K. Paik, R. Kang, S. Y. Kim, S. H. Lee, and J. H. Lee, “Increased oxidative stress in normal-weight postmenopausal women with metabolic syndrome compared with metabolically healthy overweight/obese individuals,” Metabolism: Clinical and Experimental, vol. 62, no. 4, pp. 554–560, 2013. View at Publisher · View at Google Scholar · View at Scopus
  7. J. Kosola, J. P. Vaara, M. Ahotupa et al., “Elevated concentration of oxidized LDL together with poor cardiorespiratory and abdominal muscle fitness predicts metabolic syndrome in young men,” Metabolism: Clinical and Experimental, vol. 62, no. 7, pp. 992–999, 2013. View at Publisher · View at Google Scholar · View at Scopus
  8. M. T. Mitjavila, M. Fandos, J. Salas-Salvadó et al., “The Mediterranean diet improves the systemic lipid and DNA oxidative damage in metabolic syndrome individuals. A randomized, controlled, trial,” Clinical Nutrition, vol. 32, no. 2, pp. 172–178, 2013. View at Publisher · View at Google Scholar · View at Scopus
  9. S. H. Park, J. Y. Kim, J. H. Lee, and H. Y. Park, “Elevated oxidized low-density lipoprotein concentrations in postmenopausal women with the metabolic syndrome,” Clinica Chimica Acta, vol. 412, no. 5-6, pp. 435–440, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. T. Yokota, S. Kinugawa, M. Yamato et al., “Systemic oxidative stress is associated with lower aerobic capacity and impaired skeletal muscle energy metabolism in patients withmetabolic syndrome,” Diabetes Care, vol. 36, no. 5, pp. 1341–1346, 2013. View at Publisher · View at Google Scholar · View at Scopus
  11. E. M. Yubero-Serrano, J. Delgado-Lista, P. Peña-Orihuela et al., “Oxidative stress is associated with the number of components of metabolic syndrome: LIPGENE study,” Experimental and Molecular Medicine, vol. 45, no. 6, article e28, 2013. View at Publisher · View at Google Scholar · View at Scopus
  12. E. Leiva, V. Mujica, P. Sepúlveda et al., “High levels of iron status and oxidative stress in patients with metabolic syndrome,” Biological Trace Element Research, vol. 151, no. 1, pp. 1–8, 2013. View at Publisher · View at Google Scholar · View at Scopus
  13. I. Jialal, S. Devaraj, B. Adams-Huet, X. Chen, and H. Kaur, “Increased cellular and circulating biomarkers of oxidative stress in nascent metabolic syndrome,” Journal of Clinical Endocrinology and Metabolism, vol. 97, no. 10, pp. E1844–E1850, 2012. View at Publisher · View at Google Scholar · View at Scopus
  14. V. S. Rao, R. K. Nagaraj, S. Hebbagodi, N. B. Kadarinarasimhiah, and V. V. Kakkar, “Association of inflammatory and oxidative stress markers with metabolic syndrome in Asian Indians in India,” Cardiology Research and Practice, vol. 2011, Article ID 295976, 8 pages, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. D. Vaidya, M. Szklo, M. Cushman et al., “Association of endothelial and oxidative stress with metabolic syndrome and subclinical atherosclerosis: multi-ethnic study of atherosclerosis,” European Journal of Clinical Nutrition, vol. 65, no. 7, pp. 818–825, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. M. Matsuda, R. Tamura, K. Kanno et al., “Impact of dyslipidemic components of metabolic syndrome, adiponectin levels, and anti-diabetes medications on malondialdehyde-modified low-density lipoprotein levels in statin-treated diabetes patients with coronary artery disease,” Diabetology & Metabolic Syndrome, vol. 5, article 77, 2013. View at Publisher · View at Google Scholar
  17. S. Park, M. Kim, J. K. Paik, Y. J. Jang, S. H. Lee, and J. H. Lee, “Oxidative stress is associated with C-reactive protein in nondiabetic postmenopausal women, independent of obesity and insulin resistance,” Clinical Endocrinology, vol. 79, no. 1, pp. 65–70, 2013. View at Publisher · View at Google Scholar · View at Scopus
  18. G. Caimi, E. Hopps, M. Montana et al., “Evaluation of nitric oxide metabolites in a group of subjects with metabolic syndrome,” Diabetes and Metabolic Syndrome: Clinical Research and Reviews, vol. 6, no. 3, pp. 132–135, 2012. View at Publisher · View at Google Scholar · View at Scopus
  19. S. Zahedi Asl, A. Ghasemi, and F. Azizi, “Serum nitric oxide metabolites in subjects with metabolic syndrome,” Clinical Biochemistry, vol. 41, no. 16-17, pp. 1342–1347, 2008. View at Publisher · View at Google Scholar · View at Scopus
  20. M. C. Stühlinger, F. Abbasi, J. W. Chu et al., “Relationship between insulin resistance and an endogenous nitric oxide synthase inhibitor,” Journal of the American Medical Association, vol. 287, no. 11, pp. 1420–1426, 2002. View at Google Scholar · View at Scopus
  21. P. Chedraui, G. S. Escobar, C. Ramírez et al., “Nitric oxide and pro-inflammatory cytokine serum levels in postmenopausal women with the metabolic syndrome,” Gynecological Endocrinology, vol. 28, no. 10, pp. 787–791, 2012. View at Publisher · View at Google Scholar · View at Scopus
  22. S. Moncada, R. M. J. Palmer, and E. A. Higgs, “Nitric oxide: physiology, pathophysiology, and pharmacology,” Pharmacological Reviews, vol. 43, no. 2, pp. 109–142, 1991. View at Google Scholar · View at Scopus
  23. U. Förstermann, H. Kleinert, I. Gath, P. Schwarz, E. I. Closs, and N. J. Dun, “Expression and expressional control of nitric oxide synthases in various cell types,” Advances in Pharmacology, vol. 34, pp. 171–186, 1995. View at Publisher · View at Google Scholar · View at Scopus
  24. J. B. Weinberg, “Nitric oxide production and nitric oxide synthase type 2 expression by human mononuclear phagocytes: a review,” Molecular Medicine, vol. 4, no. 9, pp. 557–591, 1998. View at Google Scholar · View at Scopus
  25. M. Olszanecka-Glinianowicz, B. Zahorska-Markiewicz, J. Janowska, and A. Zurakowski, “Serum concentrations of nitric oxide, tumor necrosis factor (TNF)-α and TNF soluble receptors in women with overweight and obesity,” Metabolism: Clinical and Experimental, vol. 53, no. 10, pp. 1268–1273, 2004. View at Publisher · View at Google Scholar · View at Scopus
  26. F. O. Pereira, T. S. Frode, and Y. S. Medeiros, “Evaluation of tumour necrosis factor alpha, interleukin-2 soluble receptor, nitric oxide metabolites, and lipids as inflammatory markers in type 2 diabetes mellitus,” Mediators of Inflammation, vol. 2006, Article ID 39062, 7 pages, 2006. View at Publisher · View at Google Scholar · View at Scopus
  27. S. M. Ouvia, R. D. La Greca, N. L. Zanaro, L. Palmer, and B. Sassetti, “Endothelial dysfunction, nitric oxide and platelet activation in hypertensive and diabetic type II patients,” Thrombosis Research, vol. 102, no. 2, pp. 107–114, 2001. View at Publisher · View at Google Scholar · View at Scopus
  28. L. di Renzo, F. Galvano, C. Orlandi et al., “Oxidative stress in normal-weight obese syndrome,” Obesity, vol. 18, no. 11, pp. 2125–2130, 2010. View at Publisher · View at Google Scholar · View at Scopus
  29. C. A. Kumar and U. N. Das, “Lipid peroxides, anti-oxidants and nitric oxide in patients with pre-eclampsia and essential hypertension,” Medical Science Monitor, vol. 6, no. 5, pp. 901–907, 2000. View at Google Scholar · View at Scopus
  30. S. Túri, A. Friedman, C. Bereczki et al., “Oxidative stress in juvenile essential hypertension,” Journal of Hypertension, vol. 21, no. 1, pp. 145–152, 2003. View at Publisher · View at Google Scholar · View at Scopus
  31. Á. Baráth, I. Németh, E. Karg et al., “Roles of paraoxonase and oxidative stress in adolescents with uraemic, essential or obesity-induced hypertension,” Kidney and Blood Pressure Research, vol. 29, no. 3, pp. 144–151, 2006. View at Publisher · View at Google Scholar · View at Scopus
  32. Á. Baráth, S. Túri, I. Németh et al., “Different pathomechanisms of essential and obesity-associated hypertension in adolescents,” Pediatric Nephrology, vol. 21, no. 10, pp. 1419–1425, 2006. View at Publisher · View at Google Scholar · View at Scopus
  33. L. Díaz González, S. Suárez García, V. López Fernández, A. Álvarez Cosmea, M. T. Arias García, and F. Álvarez Menéndez, “Identification of individuals with insulin resistance by means of clinical measurements and routine biochemical markers. Construction of an individual risk index,” Revista Clinica Espanola, vol. 207, no. 6, pp. 271–277, 2007. View at Publisher · View at Google Scholar · View at Scopus
  34. A. González-Chávez, L. E. Simental-Mendía, and S. Elizondo-Argueta, “Elevated triglycerides/HDL-cholesterol ratio associated with insulin resistance,” Cirugia y Cirujanos, vol. 79, no. 2, pp. 126–131, 2011. View at Google Scholar · View at Scopus
  35. J. Soutelo, M. Graffigna, M. Honfi et al., “Triglicéridos/HDL-cholesterol ratio: in adolescents without cardiovascular risk factors,” Archivos Latinoamericanos de Nutricion, vol. 62, no. 2, pp. 167–171, 2012. View at Google Scholar · View at Scopus
  36. M. H. Tan, D. Johns, and N. B. Glazer, “Pioglitazone reduces atherogenic index of plasma in patients with type 2 diabetes,” Clinical Chemistry, vol. 50, no. 7, pp. 1184–1188, 2004. View at Publisher · View at Google Scholar · View at Scopus
  37. K. G. M. M. Alberti, P. Zimmet, and J. Shaw, “The metabolic syndrome—a new worldwide definition,” The Lancet, vol. 366, no. 9491, pp. 1059–1062, 2005. View at Publisher · View at Google Scholar · View at Scopus
  38. C. di Massimo, P. Scarpelli, N. D. Lorenzo, G. Caimi, F. D. Orio, and M. G. T. Ciancarelli, “Impaired plasma nitric oxide availability and extracellular superoxide dismutase activity in healthy humans with advancing age,” Life Sciences, vol. 78, no. 11, pp. 1163–1167, 2006. View at Publisher · View at Google Scholar · View at Scopus
  39. R. W. Nims, J. F. Darbyshire, J. E. Saavedra et al., “Colorimetric methods for the determination of nitric oxide concentration in neutral aqueous solutions,” Methods: A Companion to Methods in Enzymology, vol. 7, no. 1, pp. 48–54, 1995. View at Publisher · View at Google Scholar · View at Scopus
  40. A. N. C. Simão, M. A. B. Lozovoy, T. N. C. Simão et al., “Immunological and biochemical parameters of patients with metabolic syndrome and the participation of oxidative and nitroactive stress,” Brazilian Journal of Medical and Biological Research, vol. 44, no. 7, pp. 707–712, 2011. View at Publisher · View at Google Scholar · View at Scopus
  41. I. Zavaroni, D. Ardigo, P. C. Rossi et al., “Relationship between plasma nitric oxide concentration and insulin resistance in essential hypertension,” American Journal of Hypertension, vol. 17, no. 7, pp. 549–552, 2004. View at Publisher · View at Google Scholar · View at Scopus
  42. W. Y. Chien, K. D. Yang, H. L. Eng et al., “Increased plasma concentration of nitric oxide in type 2 diabetes but not in nondiabetic individuals with insulin resistance,” Diabetes and Metabolism, vol. 31, no. 1, pp. 63–68, 2005. View at Google Scholar · View at Scopus
  43. M. J. Shin, J. H. Lee, Y. Jang et al., “Insulin resistance, adipokines, and oxidative stress in nondiabetic, hypercholesterolemic patients: leptin as an 8-epi-prostaglandin F2α determinant,” Metabolism: Clinical and Experimental, vol. 55, no. 7, pp. 918–922, 2006. View at Publisher · View at Google Scholar · View at Scopus
  44. H. N. Cha, Y. W. Kim, J. Y. Kim et al., “Lack of inducible nitric oxide synthase does not prevent aging-associated insulin resistance,” Experimental Gerontology, vol. 45, no. 9, pp. 711–718, 2010. View at Publisher · View at Google Scholar · View at Scopus
  45. H. N. Cha, S. E. Song, Y. W. Kim, J. Y. Kim, K. C. Won, and S. Y. Park, “Lack of inducible nitric oxide synthase prevents lipid-induced skeletal muscle insulin resistance without attenuating cytokine level,” Journal of Pharmacological Sciences, vol. 117, no. 2, pp. 77–86, 2011. View at Publisher · View at Google Scholar · View at Scopus
  46. N. J. Pillon, R. E. Vella, L. Soulère, M. Becchi, M. Lagarde, and C. O. Soulage, “Structural and functional changes in human insulin induced by the lipid peroxidation byproducts 4-hydroxy-2-nonenal and 4-hydroxy-2-hexenal,” Chemical Research in Toxicology, vol. 24, no. 5, pp. 752–762, 2011. View at Publisher · View at Google Scholar · View at Scopus
  47. N. J. Pillon, M. L. Croze, R. E. Vella, L. Soulère, M. Lagarde, and C. O. Soulage, “The lipid peroxidation by-product 4-hydroxy-2-nonenal (4-HNE) induces insulin resistance in skeletal muscle through both carbonyl and oxidative stress,” Endocrinology, vol. 153, no. 5, pp. 2099–2111, 2012. View at Publisher · View at Google Scholar · View at Scopus
  48. K. H. Ingram, H. Hill, D. R. Moellering et al., “Skeletal muscle lipid peroxidation and insulin resistance in humans,” Journal of Clinical Endocrinology and Metabolism, vol. 97, no. 7, pp. E1182–E1186, 2012. View at Publisher · View at Google Scholar · View at Scopus
  49. G. Murdolo, M. Piroddi, F. Luchetti et al., “Oxidative stress and lipid peroxidation by-products at the crossroad between adipose organ dysregulation and obesity-linked insulin resistance,” Biochimie, vol. 95, no. 3, pp. 585–594, 2013. View at Publisher · View at Google Scholar · View at Scopus
  50. K. Komosińska-Vassev, K. Olczyk, P. Olczyk, and K. Winsz-Szczotka, “Effects of metabolic control and vascular complications on indices of oxidative stress in type 2 diabetic patients,” Diabetes Research and Clinical Practice, vol. 68, no. 3, pp. 207–216, 2005. View at Publisher · View at Google Scholar · View at Scopus
  51. C. Chrysohoou, D. B. Panagiotakos, C. Pitsavos et al., “The association between pre-hypertension status and oxidative stress markers related to atherosclerotic disease: the ATTICA study,” Atherosclerosis, vol. 192, no. 1, pp. 169–176, 2007. View at Publisher · View at Google Scholar · View at Scopus
  52. N. Abdilla, M. C. Tormo, M. J. Fabia, F. J. Chaves, G. Saez, and J. Redon, “Impact of the components of metabolic syndrome on oxidative stress and enzymatic antioxidant activity in essential hypertension,” Journal of Human Hypertension, vol. 21, no. 1, pp. 68–75, 2007. View at Publisher · View at Google Scholar · View at Scopus
  53. M. A. Sánchez-Rodríguez, M. Martínez-Cruz, E. Correa-Muñoz, and V. M. Mendoza-Núñez, “Relationship between metabolic syndrome components and oxidative stress in elderly community-dwelling Mexicans,” Annals of Nutrition & Metabolism, vol. 56, no. 4, pp. 302–307, 2010. View at Publisher · View at Google Scholar
  54. A. G. Pirinccioglu, D. Gökalp, M. Pirinccioglu, G. Kizil, and M. Kizil, “Malondialdehyde (MDA) and protein carbonyl (PCO) levels as biomarkers of oxidative stress in subjects with familial hypercholesterolemia,” Clinical Biochemistry, vol. 43, no. 15, pp. 1220–1224, 2010. View at Publisher · View at Google Scholar · View at Scopus
  55. M. Toprakci, D. Ozmen, I. Mutaf et al., “Age-associated changes in nitric oxide metabolites nitrite and nitrate,” International Journal of Clinical and Laboratory Research, vol. 30, no. 2, pp. 83–85, 2000. View at Publisher · View at Google Scholar · View at Scopus
  56. A. Ghasemi, S. Zahedi Asl, Y. Mehrabi, N. Saadat, and F. Azizi, “Serum nitric oxide metabolite levels in a general healthy population: relation to sex and age,” Life Sciences, vol. 83, no. 9-10, pp. 326–331, 2008. View at Publisher · View at Google Scholar · View at Scopus
  57. R. Li, D. Lyn, R. Lapu-Bula et al., “Relation of endothelial nitric oxide synthase gene to plasma nitric oxide level, endothelial function, and blood pressure in African Americans,” American Journal of Hypertension, vol. 17, no. 7, pp. 560–567, 2004. View at Publisher · View at Google Scholar · View at Scopus
  58. J. W. Choi, “Enhanced nitric oxide production is closely associated with serum lipid concentrations in adolescents,” Clinica Chimica Acta, vol. 347, no. 1-2, pp. 151–156, 2004. View at Publisher · View at Google Scholar · View at Scopus
  59. G. Caimi, E. Hopps, D. Noto et al., “Protein oxidation in a group of subjects with metabolic syndrome,” Diabetes and Metabolic Syndrome: Clinical Research and Reviews, vol. 7, no. 1, pp. 38–41, 2013. View at Publisher · View at Google Scholar · View at Scopus
  60. M. P. Mattson, “Roles of the lipid peroxidation product 4-hydroxynonenal in obesity, the metabolic syndrome, and associated vascular and neurodegenerative disorders,” Experimental Gerontology, vol. 44, no. 10, pp. 625–633, 2009. View at Publisher · View at Google Scholar · View at Scopus