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Oxidative Medicine and Cellular Longevity
Volume 2014, Article ID 828702, 5 pages
Review Article

Lipid Peroxidation in Psychiatric Illness: Overview of Clinical Evidence

Department of Pharmacology, Center for Translational Medicine, Temple University School of Medicine, MERB 947, 3500 North Broad Street, Philadelphia, PA 19140, USA

Received 18 March 2014; Accepted 8 April 2014; Published 27 April 2014

Academic Editor: Kota V. Ramana

Copyright © 2014 Yash B. Joshi and Domenico Praticò. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The brain is known to be sensitive to oxidative stress and lipid peroxidation. While lipid peroxidation has been shown to contribute to many disease processes, its role in psychiatric illness has not been investigated until recently. In this paper, we provide an overview of lipid peroxidation in the central nervous system as well as clinical data supporting a link between lipid peroxidation and disorders such as schizophrenia, bipolar disorder, and major depressive disorder. These data support further investigation of lipid peroxidation in the effort to uncover therapeutic targets and biomarkers of psychiatric disease.