Taurine Rescues Cisplatin-Induced Muscle Atrophy In Vitro: A Morphological Study

Figure 5

(a) Toluidine blue-stained C2C12 myotubes exposed for 24 h to DMSO, 10 μM, or 50 μM CisPt alone or combined with Tau. Tau preserved morphology like in DMSO and 10 μM CisPt treatments, but atrophy induced by 50 μM CisPt was restored by Tau. Arrow indicated necrosis. Bar=20𝜇m. (b) Analysis of C2C12 myotubes’ size exposed to CisPt in the presence or not of Tau. ^☆𝑃≤0.05 compared with DMSO; ^∘𝑃≤0.05 compared with CisPt 50 μM (𝑛=3).

(a)

(b)