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Oxidative Medicine and Cellular Longevity
Volume 2014, Article ID 858604, 7 pages
Research Article

Oxidative Stress Induced in Nurses by Exposure to Preparation and Handling of Antineoplastic Drugs in Mexican Hospitals: A Multicentric Study

1Laboratorio de Toxicología Ambiental, Facultad de Química, Universidad Autónoma del Estado de México, 50120 Toluca, MEX, Mexico
2Centro Oncológico Estatal del Instituto de Seguridad Social del Estado de México y Municipios, 50180 Toluca, MEX, Mexico
3Laboratorio de Toxicología Acuática, Departamento de Farmacia, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, 07700 México, DF, Mexico

Received 28 December 2013; Revised 17 January 2014; Accepted 21 January 2014; Published 26 February 2014

Academic Editor: Kota V. Ramana

Copyright © 2014 Leobardo Manuel Gómez-Oliván et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The impact of involuntary exposure to antineoplastic drugs (AD) was studied in a group of nurses in diverse hospitals in Mexico. The results were compared with a group of unexposed nurses. Anthropometric characteristics and the biochemical analysis were analyzed in both groups. Also, lipid peroxidation level (LPX), protein carbonyl content (PCC), and activity of the antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) were evaluated in blood of study participants as oxidative stress (OS) biomarkers. The group of occupationally exposed (OE) nurses consisted of 30 individuals ranging in age from 25 to 35 years. The control group included 30 nurses who were not occupationally exposed to the preparation and handling of AD and whose anthropometric and biochemical characteristics were similar to those of the OE group. All biomarkers evaluated were significantly increased ( ) in OE nurses compared to the control group. Results show that the assessment of OS biomarkers is advisable in order to evaluate exposure to AD in nurses.