Table of Contents Author Guidelines Submit a Manuscript
Table of Contents Alerts

To receive news and publication updates for Oxidative Medicine and Cellular Longevity, enter your email address in the box below.

Oxidative Medicine and Cellular Longevity
Volume 2014 (2014), Article ID 858604, 7 pages
http://dx.doi.org/10.1155/2014/858604
Research Article

Oxidative Stress Induced in Nurses by Exposure to Preparation and Handling of Antineoplastic Drugs in Mexican Hospitals: A Multicentric Study

Leobardo Manuel Gómez-Oliván,1 Gerardo Daniel Miranda-Mendoza,1 Paula Anel Cabrera-Galeana,2 Marcela Galar-Martínez,3 Hariz Islas-Flores,1 Nely SanJuan-Reyes,1 Nadia Neri-Cruz,1 and Sandra García-Medina3

1Laboratorio de Toxicología Ambiental, Facultad de Química, Universidad Autónoma del Estado de México, 50120 Toluca, MEX, Mexico
2Centro Oncológico Estatal del Instituto de Seguridad Social del Estado de México y Municipios, 50180 Toluca, MEX, Mexico
3Laboratorio de Toxicología Acuática, Departamento de Farmacia, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, 07700 México, DF, Mexico

Received 28 December 2013; Revised 17 January 2014; Accepted 21 January 2014; Published 26 February 2014

Academic Editor: Kota V. Ramana

Copyright © 2014 Leobardo Manuel Gómez-Oliván et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. S. Sohal, “Role of oxidative stress and protein oxidation in the aging process,” Free Radical Biology and Medicine, vol. 33, no. 1, pp. 37–44, 2002. View at Publisher · View at Google Scholar · View at Scopus
  2. U. Singh and I. Jialal, “Oxidative stress and atherosclerosis,” Pathophysiology, vol. 13, no. 3, pp. 129–142, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. J. Ferri, S. Martínez-Hervás, O. Espinosa et al., “8-oxo-7,8-dihydro-2′-deoxyguanosine as a marker of DNA oxidative stress in individuals with combined familiar hyperlipidemia,” Medicina Clinica, vol. 131, no. 1, pp. 1–4, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. N. Abdilla, M. C. Tormo, M. J. Fabia, F. J. Chaves, G. Saez, and J. Redon, “Impact of the components of metabolic syndrome on oxidative stress and enzymatic antioxidant activity in essential hypertension,” Journal of Human Hypertension, vol. 21, no. 1, pp. 68–75, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. M. Krzystek-Korpacka, E. Patryn, D. Boehm, I. Berdowska, B. Zielinski, and A. Noczynska, “Advanced oxidation protein products (AOPPs) in juvenile overweight and obesity prior to and following weight reduction,” Clinical Biochemistry, vol. 41, no. 12, pp. 943–949, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. T. M. Millar, V. Phan, and L. A. Tibbles, “ROS generation in endothelial hypoxia and reoxygenation stimulates MAP kinase signaling and kinase-dependent neutrophil recruitment,” Free Radical Biology and Medicine, vol. 42, no. 8, pp. 1165–1177, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. J. B. Seal and B. L. Gewertz, “Vascular dysfunction in ischemia-reperfusion injury,” Annals of Vascular Surgery, vol. 19, no. 4, pp. 572–584, 2005. View at Publisher · View at Google Scholar · View at Scopus
  8. N. Mucci, A. Ianni, C. L. Ursini, M. Orsini, D. Arzani, and V. Romano-Spica, “Cytostatic drugs and health risks for exposed personnel: search for new biomarkers,” Anticancer Research, vol. 20, no. 5, pp. 2995–3000, 2000. View at Google Scholar · View at Scopus
  9. A. Marczak and Z. Jóźwiak, “Damage to the cell antioxidative system in human erythrocytes incubated with idarubicin and glutaraldehyde,” Toxicology in Vitro, vol. 23, no. 6, pp. 1188–1194, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. L. P. Rybak, C. A. Whitworth, D. Mukherjea, and V. Ramkumar, “Mechanisms of cisplatin-induced ototoxicity and prevention,” Hearing Research, vol. 226, no. 1-2, pp. 157–167, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. H. D. Scheibmeir, K. Christensen, S. H. Whitaker, J. Jegaethesan, R. Clancy, and J. D. Pierce, “A review of free radicals and antioxidants for critical care nurses,” Intensive and Critical Care Nursing, vol. 21, no. 1, pp. 24–28, 2005. View at Publisher · View at Google Scholar · View at Scopus
  12. S.-S. Zhang, H.-Q. Zhang, D. Li et al., “A novel benzotriazole derivative inhibits proliferation of human hepatocarcinoma cells by increasing oxidative stress concomitant mitochondrial damage,” European Journal of Pharmacology, vol. 584, no. 1, pp. 144–152, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. M. McDiarmid and T. Egan, “Acute occupational exposure to antineoplastic agents,” Journal of Occupational Medicine, vol. 30, no. 12, pp. 984–987, 1988. View at Google Scholar · View at Scopus
  14. J. Fuchs, J. G. Hengstler, D. Jung, G. Hiltl, J. Konietzko, and F. Oesch, “DNA damage in nurses handling antineoplastic agents,” Mutation Research, vol. 342, no. 1-2, pp. 17–23, 1995. View at Publisher · View at Google Scholar · View at Scopus
  15. B. Valanis, W. M. Vollmer, and P. Steele, “Occupational exposure to antineoplastic agents: self-reported miscarriages and stillbirths among nurses and pharmacists,” Journal of Occupational and Environmental Medicine, vol. 41, no. 8, pp. 632–638, 1999. View at Publisher · View at Google Scholar · View at Scopus
  16. R. Turci, C. Sottani, A. Ronchi, and C. Minoia, “Biological monitoring of hospital personnel occupationally exposed to antineoplastic agents,” Toxicology Letters, vol. 134, no. 1–3, pp. 57–64, 2002. View at Publisher · View at Google Scholar · View at Scopus
  17. S. Gao, A. Mobley, C. Miller, J. Boklan, and J. Chandra, “Potentiation of reactive oxygen species is a marker for synergistic cytotoxicity of MS-275 and 5-azacytidine in leukemic cells,” Leukemia Research, vol. 32, no. 5, pp. 771–780, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. F. Rombaldi, C. Cassini, M. Salvador, J. Saffi, and B. Erdtmann, “Occupational risk assessment of genotoxicity and oxidative stress in workers handling anti-neoplastic drugs during a working week,” Mutagenesis, vol. 24, no. 2, pp. 143–148, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. T. Ulas, H. Buyukhatipoglu, I. Kirhan et al., “Evaluation of oxidative stress parameters and metabolic activities of nurses working day and night shifts,” Revista da Escola de Enfermagem, vol. 47, no. 2, pp. 471–476, 2013. View at Google Scholar
  20. T. Ulas, H. Buyukhatipoglu, I. Kirhan et al., “The effect of day and night shifts on oxidative stress and anxiety symptoms of the nurses,” European Review for Medical and Pharmacological Sciences, vol. 16, pp. 594–599, 2012. View at Google Scholar
  21. J. A. Büege and S. D. Aust, “Microsomal lipid peroxidation,” Methods in Enzymology, vol. 52, pp. 302–310, 1978. View at Google Scholar
  22. R. L. Levine, J. A. Williams, E. R. Stadtman, and E. Shacter, “Carbonyl assays for determination of oxidatively modified proteins,” Methods in Enzymology, vol. 233, pp. 346–357, 1994. View at Publisher · View at Google Scholar · View at Scopus
  23. H. P. Misra and I. Fridovich, “The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase,” The Journal of Biological Chemistry, vol. 247, no. 10, pp. 3170–3175, 1972. View at Google Scholar · View at Scopus
  24. R. Radi, J. F. Turrens, L. Y. Chang, K. M. Bush, J. D. Crapo, and B. A. Freeman, “Detection of catalase in rat heart mitochondria,” The Journal of Biological Chemistry, vol. 266, no. 32, pp. 22028–22034, 1991. View at Google Scholar · View at Scopus
  25. W. Gunzler and A. Flohe-Clairborne, “Glutathione peroxidase,” in Handbook of Methods for Oxygen Radical Research, CRC Press, Boca Raton, Fla, USA, 1985. View at Google Scholar
  26. I. Andreadou, F. Sigala, E. K. Iliodromitis et al., “Acute doxorubicin cardiotoxicity is successfully treated with the phytochemical oleuropein through suppression of oxidative and nitrosative stress,” Journal of Molecular and Cellular Cardiology, vol. 42, no. 3, pp. 549–558, 2007. View at Publisher · View at Google Scholar · View at Scopus
  27. F. M. Santandreu, P. Roca, and J. Oliver, “Uncoupling protein-2 knockdown mediates the cytotoxic effects of cisplatin,” Free Radical Biology and Medicine, vol. 49, no. 4, pp. 658–666, 2010. View at Publisher · View at Google Scholar · View at Scopus
  28. S. Deng, A. Kruger, A. L. Kleschyov, L. Kalinowski, A. Daiber, and L. Wojnowski, “Gp91phox-containing NAD(P)H oxidase increases superoxide formation by doxorubicin and NADPH,” Free Radical Biology and Medicine, vol. 42, no. 4, pp. 466–473, 2007. View at Publisher · View at Google Scholar · View at Scopus
  29. B. A. Wagner, C. B. Evig, K. J. Reszka, G. R. Buettner, and C. P. Burns, “Doxorubicin increases intracellular hydrogen peroxide in PC3 prostate cancer cells,” Archives of Biochemistry and Biophysics, vol. 440, no. 2, pp. 181–190, 2005. View at Publisher · View at Google Scholar · View at Scopus
  30. D. Stuehr, S. Pou, and G. M. Rosen, “Oxygen reduction by nitric-oxide synthases,” The Journal of Biological Chemistry, vol. 276, no. 18, pp. 14533–14536, 2001. View at Publisher · View at Google Scholar · View at Scopus
  31. H. Jaeschke, T. R. Knight, and M. L. Bajt, “The role of oxidant stress and reactive nitrogen species in acetaminophen hepatotoxicity,” Toxicology Letters, vol. 144, no. 3, pp. 279–288, 2003. View at Publisher · View at Google Scholar · View at Scopus
  32. A. Denicola and R. Radi, “Peroxynitrite and drug-dependent toxicity,” Toxicology, vol. 208, no. 2, pp. 273–288, 2005. View at Publisher · View at Google Scholar · View at Scopus
  33. F. Bernuzzi, S. Recalcati, A. Alberghini, and G. Cairo, “Reactive oxygen species-independent apoptosis in doxorubicin-treated H9c2 cardiomyocytes: role for heme oxygenase-1 down-modulation,” Chemico-Biological Interactions, vol. 177, no. 1, pp. 12–20, 2009. View at Publisher · View at Google Scholar · View at Scopus
  34. D. A. Gewirtz, “A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin,” Biochemical Pharmacology, vol. 57, no. 7, pp. 727–741, 1999. View at Publisher · View at Google Scholar · View at Scopus
  35. T. Kimura, I. Fujita, N. Itoh et al., “Metallothionein acts as a cytoprotectant against doxorubicin toxicity,” Journal of Pharmacology and Experimental Therapeutics, vol. 292, no. 1, pp. 299–302, 2000. View at Google Scholar · View at Scopus
  36. J. L. Quiles, J. R. Huertas, M. Battino, J. Mataix, and M. C. Ramírez-Tortosa, “Antioxidant nutrients and adriamycin toxicity,” Toxicology, vol. 180, no. 1, pp. 79–95, 2002. View at Publisher · View at Google Scholar · View at Scopus
  37. K. Sugihara and M. Gemba, “Modification of cisplatin toxicity by antioxidants,” Japanese Journal of Pharmacology, vol. 40, no. 2, pp. 353–355, 1986. View at Google Scholar · View at Scopus
  38. Y. Lu, A. Kawashima, I. Horii, and L. Zhong, “Cisplatin-induced cytotoxicity in BSO-exposed renal proximal tubular epithelial cells: sex, age, and species,” Renal Failure, vol. 27, no. 5, pp. 629–633, 2005. View at Publisher · View at Google Scholar · View at Scopus
  39. Y. Lu and A. I. Cederbaum, “Cisplatin-induced hepatotoxicity is enhanced by elevated expression of cytochrome P450 2E1,” Toxicological Sciences, vol. 89, no. 2, pp. 515–523, 2006. View at Publisher · View at Google Scholar · View at Scopus
  40. G. Tilman, “Oxidants and antioxidants defense systems,” in The Handbook of Enviromental Chemistry 2.0, Springer, New York, NY, USA, 2005. View at Google Scholar
  41. M. Newman and M. Unger, Fundamentals of Ecotoxicology, Lewis, Chelsea, Mich, USA, 2nd edition, 2003.