Psoralea corylifolia L. Seed Extract Ameliorates Streptozotocin-Induced Diabetes in Mice by Inhibition of Oxidative Stress

Figure 4

Antiapoptotic effect of psolaren and isopsolaren, PCS extract components, in H₂O₂-treated INS-1 cells. (a)–(d) INS-1 cells were treated without (−) or with various doses of PCS extract (a) or components of PCS extract ((b) bakuchiol, (c) psoralen, and (d) isopsoralen) for 24 h, and 100 μM H₂O₂ was added for the last 1 h. Cell viability was measured by a CCK-8 assay kit. *𝑃<0.05 versus (−)/H₂O₂. (e) Extracted ion chromatograms and MS² spectrums for psoralen and isopsoralen. Ion chromatograms ([M + H] = 187.0386) were extracted from psoralen (1 μg/mL), isopsoralen (1 μg/mL), and PCS extract (100 μg/mL) chromatograms. MS² spectrums were obtained from each compound and PCS extract.

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