Circulating Levels of Sirtuin 4, a Potential Marker of Oxidative Metabolism, Related to Coronary Artery Disease in Obese Patients Suffering from NAFLD, with Normal or Slightly Increased Liver Enzymes
Table 1
Characteristics of the population.
Population ()
Obese patients (140)
Healthy subjects (20)
Cross-sectional study
Parameter
Mean ± SD or median plus (25–75 IQR)
Mean ± SD or median plus (25–75 IQR)
Significance
Age (years)
46 (32–53)
23.5 (19–26)
Gender M/F
62
9
Obesity degree I/II/III ()
20/42/78
0
BMI
42.1 ± 7.4
22.3 ± 1.1
WC females cm
117.8 ± 13.2
82.7 ± 3.7
WC males cm
131.6 ± 16
82 ± 2.8
W-H ratio females
0.93 ± 0.05
1.17 ± 0.03
W-H ratio males
1 ± 0.04
1.17 ± 0.04
HS grade 1/2/3 US ()
32/86/22
0
IMTG score I/II/III/IV US ()
34/96/4/6
0
SIRT4 ng/mL
1.2 (0.8–1.8)
8 (1.2–15)
HOMA
2.62 (1.53–4.15)
0.43 (0.41–0.48)
Triglycerides mg/dL
128 (93.7–174.5)
103 (98–128)
HDL females mg/dL
49.5 ± 12.9
59.5 ± 6.0
HDL males mg/dL
40.0 ± 10.1
50 ± 4.3
cIMT mm
0.1 (0.07–0.11)
0.06 (0.05-0.06)
CRP mg/mL
0.52 (0.30–0.08)
0.12 (0.1–0.18)
Fibrinogen g/L
310.7 ± 71.1
267.0 ± 33.7
Ferritin females ng/mL
71.1 (21.5–72.29)
68.2 (26–81.3)
Ferritin males ng/mL
116 (78–222.5)
108 (58.3–207.4)
SLD cm
11.28 ± 1.4
9.8 ± 0.6
RMR/FMM
39.5 ± 7.5
42 ± 3.8
ALT U/L
27 (21–36.5)
16 (13–20)
Gamma-GT U/L
24 (16–36.2)
15.5 (11–17)
AP
75.9 ± 25.5
97.5 ± 6.7
PCH
9375 ± 1793
8781 ± 1210
Body mass index (BMI); waist circumference (WC); resting metabolic rate/free fat mass (RMR/FFM); high density lipoprotein cholesterol (HDL); common carotid intima-media thickness (IMT); waist-to-hip (WH); hepatic steatosis (HS) score; ultrasound (US); spleen longitudinal diameter (SLD), C-reactive protein (CRP); homeostatic metabolic assessment (HOMA); alanine aminotransferase (ALT); pseudocholinesterase (PCH); alkaline phosphatase (AP); gamma-glutamyl transpeptidase (gamma-GT).
