Effects of Downregulation of MicroRNA-181a on H₂O₂-Induced H9c2 Cell Apoptosis via the Mitochondrial Apoptotic Pathway

Figure 2

miRNA expression changes in H₂O₂-induced apoptotic cardiomyocytes. (a) Fold change in miR-7a, 125a, 181a, and 423 expression after exposure to H₂O₂ (400 μM) for 2 h. ^∗𝑃<0.01 versus control (CTL); the values represent the mean ± SEM, 𝑛=3. (b) H9c2 cells were treated with different concentrations of H₂O₂, ranging from 50 to 800 μM for 2 h. ^∗𝑃<0.05 versus control (CTL); ^∗∗𝑃<0.01 versus control (CTL); the values represent the mean ± SEM, 𝑛=3.

(a)

(b)