Urinary Excretion of Neutrophil Gelatinase-Associated Lipocalin in Diabetic Rats

Table 1

Biochemical and physical characteristics of experimental groups.

	Control		Diabetic		Diabetic insulin treated
	7 days	30 days	7 days	30 days	7 days	30 days
Body weight (g)	259 ± 3.34	416.0 ± 8.13	279 ± 3.08	263.5 ± 7.28*	269 ± 5.662	372.8 ± 16.59^+
Blood glucose (mg/dL)	91.16 ± 5.04	91.75 ± 4.27	402.12 ± 21.47*	402.11 ± 24.61*	101.2 ± 7.002^+	102.8 ± 5.787^+
Serum creatinine (mg/dL)	0.45 ± 0.03	0.47 ± 0.08	0.48 ± 0.05	0.39 ± 0.09	0.42 ± 0.02	0.41 ± 0.02
Diuresis (mL/24 hrs)	14.45 ± 1.47	16.3 ± 4.3	22.82 ± 3.72*	37.26 ± 3.55*	16 ± 1.3^+	16.69 ± 2.8^+
Glycosuria (mg/dL)	1.06 ± 0.06	0 ± 0	4797.1 ± 148.4*	4605.55 ± 130.94*	2.50 ± 1.12^+	6.2 ± 2.44^+
Urine creatinine (mg/mL/24 hrs)	6.26 ± 0.33	6.52 ± 1.56	8.21 ± 0.61	9.41 ± 0.59*	4.87 ± 0.72	5.72 ± 1.21^+
Proteinuria (mg/24 hrs)	19.36 ± 1.79	14.43 ± 1.51	25.87 ± 2.51	37.26 ± 3.55*	17.4 ± 1.29	11.62 ± 3.97^+
Glomerular filtration rate (mL/min)	ND	1.39 ± 0.10	ND	3.519 ± 0.46*	ND	1.725 ± 0.25^+
Albuminuria (g/24 hrs)	206 ± 23.42	189.4 ± 26.61	252 ± 40.19	446.6 ± 55.24*	247.2 ± 19.63	178.6 ± 23.92^+
Creatinine clearance (mL/min)	0.99 ± 0.09	1.02 ± 0.18	0.99 ± 0.08	1.87 ± 0.3*	0.91 ± 0.16	0.79 ± 0.17^+

ND: not determined. Data are mean ± SEM of 8 animals in each group. versus control; versus diabetic.