Cardiovascular Complications of Sleep Apnea: Role of Oxidative Stress

Table 1

Cohort studies regarding OSA and incidence of cardiovascular disease.

Cardiovascular disease	Cohort	Sample size	Duration (years)	Findings	Reference
Hypertension	WSC	893	4 or 8	Adjusted OR of AHI ≥ 15, compared with AHI = 0 : 2.89	[4]
Coronary artery disease	SHHS	4422	8.7	Significant association only on adjusted subgroup analysis of men ≤ 70. Adjusted HR for AHI ≥ 30 compared with AHI < 5 : 1.68	[5]
Stroke	WSC	1475	4 or 8	Age and sex adjusted OR for AHI ≥ 20, compared with AHI < 5 : 4.48, nonsignificant only when adjusted to BMI.	[6]
Atrial fibrillation	Sleep-clinic patients	3542	4.7	Unadjusted HR of AHI ≥ 5, compared with AHI < 5 : 2.18	[7]

AHI: apnea-hypopnea index, BMI: body mass index, HR: hazard ratio, OR: odds ratio, SHHS: Sleep Heart Health Study, WSC: Wisconsin Sleep Cohort.