Review Article
Cardiovascular Complications of Sleep Apnea: Role of Oxidative Stress
Table 2
Different biomarkers of oxidative stress and ROS production in rodent models of intermittent hypoxia.
| Reference | Species | Hypoxia regimen | Measured marker | Result |
| [8] | ICR mice | 8 min cycles of FIO2 8.5% and 21% for 30 days | MDA | Increased | [9] | ApoE−/−mice | 30-s cycles of FIO2 6.5%–21% 8 h/day for 4 and 12 weeks | OxLDL | Increased | [10] | C57BL/6J mice | 2 min 6% O2 and 2 min 21% O2 for 8 h/day for 1, 2, and 4 weeks | TBARS | Increased | [11] | CF-1 mice | 30-s cycles of FIO2 8% 8 h/day for 21 and 35 days | DNA damage | Increased | [10] | C57BL/6J mice | 2 min 6% O2 and 2 min 21% O2 for 8 h/day for 1, 2, and 4 weeks | Protein carbonyls | Increased | [12] | C57BL/6J mice | 30-s cycles of FIO2 4.5%–21% 8 h/day for 10 days | NADPH-dependent superoxide production | Increased | [13] | Sprague-Dawley rats | 90-s cycles of FIO2 of 5%, 20 cycle/h, 7 h/day for 14 days | Qualitative measurement of superoxide anion | Increased | [14] | Sprague-Dawley rats | 21% to 10% FIO2 for 5 s every 90 s for 4 weeks | SOD levels | Decreased |
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ApoE: apolipoprotein E, FIO2: fraction of oxygen inspired, MDA: malondialdehyde, NADPH: nicotinamide adenine dinucleotide phosphate, OxLDL: oxidized low-density lipoprotein, SOD: superoxide dismutase, TBARS: thiobarbituric acid.
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