The Role of Oxidative Stress and Autophagy in Atherosclerosis

Figure 1

Electron microscopy immunogold labeling for NOX4 in atherosclerotic human aorta. Contractile SMCs contain numerous myofilaments and few cytoplasmic organelles (a). Nox4 immunopositivity can be observed in both the nucleus and the cytoplasm. Synthetic SMCs exhibit few myofilaments, a prominent Golgi apparatus, and numerous circular vesicles (b). Synthetic SMCs show complete absence of immunolabeling for Nox4.

(a)

(b)