High Potency of a Novel Resveratrol Derivative, 3,3′,4,4′-Tetrahydroxy-trans-stilbene, against Ovarian Cancer Is Associated with an Oxidative Stress-Mediated Imbalance between DNA Damage Accumulation and Repair

Figure 2

Effect of RVT and 3,3′,4,4′-THS on the viability of ovarian cancer cells, normal human ovarian surface epithelial (HOSE) cells, and human peritoneal mesothelial cells (HPMCs). The cytotoxicity of the stilbenes was tested using MTT ((a)–(e)) and LDH release assays ((f)–(j)). The differences between the cytotoxicity curves were compared using two-way ANOVA. The values obtained using the MTT and LDH release methods and depicted in the figures were reanalyzed with CalcuSyn to establish the IC₅₀ for each stilbene and cancer cell line (see Table 1). The asterisks indicate a significant difference as compared to cells exposed to RVT. The experiments were performed in octuplicate.