High Potency of a Novel Resveratrol Derivative, 3,3′,4,4′-Tetrahydroxy-trans-stilbene, against Ovarian Cancer Is Associated with an Oxidative Stress-Mediated Imbalance between DNA Damage Accumulation and Repair

Table 2

Cytotoxicity of 3,3′,4,4′-THS against ovarian cancer cells, normal human ovarian surface epithelial (HOSE) cells, and human peritoneal mesothelial cells (HPMCs) at working concentrations of 10, 50, and 100 μM. The results are expressed as the percentage of the viability of control cells that were not subjected to 3,3′,4,4′-THS. The asterisks indicate a significant difference as compared to the control group.

	MTT assay			LDH release assay
	10 µM	50 μM	100 μM	10 μM	50 μM	100 μM
A2780	20 ± 3	14 ± 3	13 ± 3	42 ± 3	26 ± 3	22 ± 3
OVCAR-3	75 ± 3	50 ± 3	48 ± 3	62 ± 12	53 ± 3	46 ± 3
SKOV-3	40 ± 2	39 ± 4	35 ± 2	50 ± 2	32 ± 12	24 ± 7
HOSE cells	105 ± 2	100 ± 4	107 ± 2	101 ± 2	100 ± 4	102 ± 2
HPMCs	108 ± 14	100 ± 4	102 ± 2	101 ± 2	100 ± 4	102 ± 2