Oxidative Medicine and Cellular Longevity / 2015 / Article / Fig 2

Review Article

Vitamin A and Retinoids as Mitochondrial Toxicants

Figure 2

Unbalanced SOD/CAT ratio resulting in increased H2O2 production. Additionally, increased levels inhibit CAT enzyme activity allosterically leading to even more high H2O2 concentration due to accumulation of this ROS.

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