Vitamin A and Retinoids as Mitochondrial Toxicants

Table 3

Summary of in vivo effects of subacute vitamin A supplementation on mitochondrial redox parameters.

Sample	Superoxide anion radical	Mn-SOD enzyme activity	MAO enzyme activity	Reference
Cerebral cortex		Not measured	Not measured	[65]
Cerebellum		Not measured	Not measured	[65]
Substantia nigra			Unaltered	[67]
Striatum				[67]
Hypothalamus		Not measured	Not measured	[68]
Frontal cortex				[77]
Hippocampus				[77]
Liver		Not measured	Not measured	[73]
Heart	Not measured	Not measured	Not measured	—
Lung		Not measured	Not measured	[75]

Adult male rats were treated with vitamin A supplementation subacutely (see text for details).