Table 1: The effect of tocomin, α-tocopherol (TC), and α-, δ-, and γ-tocotrienols (T3) on ACh-induced endothelium-dependent and SNP-induced endothelium-independent relaxation of rat aortae in the presence of pyrogallol-induced oxidative stress.

AChSNP
pEC50 (M) (%)pEC50 (M) (%)

α-tocopherol
 Control5–7−7.09 ± 0.1895 ± 8−8.71 ± 0.10108 ± 7
 Pyrogallol5–7−7.13 ± 0.1847 ± 4#−8.46 ± 0.1497 ± 5
 Pyrogallol + α-TC 10−4 mg/mL5–7−6.52 ± 0.2147 ± 5#−8.55 ± 0.1294 ± 4
 Pyrogallol + α-TC 10−3 mg/mL5–7−6.84 ± 0.1246 ± 8#−8.35 ± 0.2896 ± 5
 Pyrogallol + α-TC 10−2 mg/mL5–7−6.97 ± 0.1570 ±  −8.57 ± 0.4290 ± 5
α-tocotrienol
 Control3–6−7.08 ± 0.1686 ± 10−8.58 ± 0.2597 ± 3
 Pyrogallol3–6−6.97 ± 0.1551 ± 2#−8.67 ± 0.2596 ± 7
 Pyrogallol + α-T3 10−3 mg/mL3–6−6.25 ± 0.2247 ± 4#−8.41 ± 0.26105 ± 4
 Pyrogallol + α-T3 10−2 mg/mL3–6−6.58 ± 0.1645 ± 5#−8.40 ± 0.0994 ± 7
 Pyrogallol + α-T3 10−1 mg/mL3–6−6.82 ± 0.2358 ± 5#−8.12 ± 0.02105 ± 4
δ-tocotrienol
 Control3–6−6.98 ± 0.1280 ± 3−8.38 ± 0.2897 ± 4
 Pyrogallol3–6−6.83 ± 0.4542 ± 10#−8.49 ± 0.2099 ± 3
 Pyrogallol + δ-T3 10−3 mg/mL3–6−6.74 ± 0.0846 ± 9#−8.73 ± 0.0798 ± 2
 Pyrogallol + δ-T3 10−2 mg/mL3–6−6.75 ± 0.2943 ± 8#−8.51 ± 0.0595 ± 8
 Pyrogallol + δ-T3 10−1 mg/mL3–6−6.64 ± 0.3046 ± 8#−8.60 ± 0.2099 ± 2
γ-tocotrienol
 Control3–6−6.71 ± 0.2493 ± 4−8.50 ± 0.8093 ± 4
 Pyrogallol3–6−6.51 ± 0.1559 ± 4#−8.45 ± 0.2098 ± 2
 Pyrogallol + γ-T3 10−3 mg/mL3–6−6.16 ± 0.1753 ± 4#−8.34 ± 0.12103 ± 1
 Pyrogallol + γ-T3 10−2 mg/mL3–6−6.71 ± 0.2755 ± 7#−8.59 ± 0.1595 ± 4
 Pyrogallol + γ-T3 10−1 mg/mL3–6−6.65 ± 0.2267 ± 1#−8.68 ± 0.2597 ± 1
Tocomin
 Control5–7−7.19 ± 0.0892 ± 3−8.69 ± 0.1897 ± 4
 Pyrogallol5–7−7.06 ± 0.1358 ± 5#−8.25 ± 0.0599 ± 2
 Pyrogallol + tocomin 10−6 mg/mL5–7−6.84 ± 0.1463 ± 6#−8.14 ± 0.24100 ± 7
 Pyrogallol + tocomin 10−5 mg/mL5–7−6.94 ± 0.1369 ± 5#−8.23 ± 0.18103 ± 4
 Pyrogallol + tocomin 10−4 mg/mL5–7−6.70 ± 0.2081 ±  −8.17 ± 0.1499 ± 2

Significantly different to control .
Significantly different to pyrogallol .
Sidak’s multiple comparison test.