Selective Nitric Oxide Synthase Inhibitor 7-Nitroindazole Protects against Cocaine-Induced Oxidative Stress in Rat Brain

Figure 1

CAT, SOD, GR, GPx, and GST activity measured in rat brain from cocaine group (15 mg/kg⁻¹, i.p., 7 days), 7-NI group (25 mg/kg⁻¹, i.p., 7 days), and cocaine + 7-NI group. Parameters: CAT (catalase), SOD (superoxide dismutase), GR (glutathione reductase), GPx (glutathione peroxidase), GST (glutathione-S-transferase). Data are expressed as mean ± SEM of six animals (Mann-Whitney test). ^*Significant difference from control values (Mann-Whitney test, ); ⁺significant difference from cocaine-treated group (Mann-Whitney test, ).

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