Selective Nitric Oxide Synthase Inhibitor 7-Nitroindazole Protects against Cocaine-Induced Oxidative Stress in Rat Brain

Table 2

Changes in nNOS activity, MDA quantity, and GSH levels in brain homogenate after multiple administration of cocaine, alone and in combination with 7-NI.

Group	nNOS activity (nmol/min/mg)	MDA nmol/g/wet tissue	GSH nmol/g/wet tissue
Control	0.604 ± 0.04	3.55 ± 0.20	1.68 ± 0.15
Cocaine	0.935 ± 0.14^*	4.65 ± 0.32^*	0.94 ± 0.10^*
7-NI	0.360 ± 0.07^*	3.50 ± 0.10	1.59 ± 0.10
7-NI + cocaine	0.535 ± 0.10^+	3.68 ± 0.15^+	1.55 ± 0.08^+

Data are expressed as mean ± SEM of six rats. ^*Significant difference from control values (Mann-Whitney test, ); ⁺significant difference from cocaine-treated group (Mann-Whitney test, ).