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Oxidative Medicine and Cellular Longevity
Volume 2015, Article ID 171756, 9 pages
Review Article

The Role of Flavonoids on Oxidative Stress in Epilepsy

1Postgraduate Program in Biotechnology, State University of Feira de Santana, 44036-900 Feira de Santana, BA, Brazil
2Department of Physiology, Federal University of Sergipe, 49100-000 São Cristóvão, SE, Brazil
3Federal University of Pernambuco, 50740-521 Recife, PE, Brazil
4Federal University of Piauí, 64049-550 Teresina, PI, Brazil
5Federal University of San Francisco Valley, 56304-205 Petrolina, PE, Brazil

Received 30 July 2014; Accepted 11 December 2014

Academic Editor: Francisco Javier Romero

Copyright © 2015 Tâmara Coimbra Diniz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Backgrounds. Oxidative stress can result from excessive free-radical production and it is likely implicated as a possible mechanism involved in the initiation and progression of epileptogenesis. Flavonoids can protect the brain from oxidative stress. In the central nervous system (CNS) several flavonoids bind to the benzodiazepine site on the GAB-receptor resulting in anticonvulsive effects. Objective. This review provides an overview about the role of flavonoids in oxidative stress in epilepsy. The mechanism of action of flavonoids and its relation to the chemical structure is also discussed. Results/Conclusions. There is evidence that suggests that flavonoids have potential for neuroprotection in epilepsy.