EGCG Attenuates Uric Acid-Induced Inflammatory and Oxidative Stress Responses by Medicating the NOTCH Pathway

Figure 2

Dose- (a) and time-dependent (b) effect of UA on Notch1 expression in HUVEC. (a) UA enhanced the expression of Notch1 at concentrations of 8 mg/dL or higher compared with control. (b) UA-induced expression of Notch1 peaked at 8 hours and remained elevated at 48 hours. (c) Western blot analysis of Hes1, Hes5, and Hey1 protein expressions in HUVEC treated with UA (8 mg/dL) for 8 hours.

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