Oxidative Medicine and Cellular Longevity

Review Article

Sleep Deprivation and Oxidative Stress in Animal Models: A Systematic Review

Table 4

Oxidative stress in brain regions during paradoxical sleep deprivation in rats.
AuthorSleep deprivation protocolMethodAnimal specieDeprivation timeBrain regions with oxidative changesGSHGSSGGSH/GSSG ratioGPxCatalaseSODNitritesNOLipid oxidation
Zhang et al. (2013) [28]PSDMSP with MLPMale Sprague Dawley rats24 & 72 hrsCerebral cortex & hippocampusNoNoNoNoNoYes ↓↓NoYes ↑↑Yes ↑↑
Hirotsu et al. (2013) [30]PSDMSPMale Wistar Hanover rats24 hrsFrontal cortexNoNoNoNoYes —Yes —NoYes —No
Alzoubi et al. (2013) [31]PSDMSP with MLPMale Wistar rats8 hrs/day for 6 weeksHippocampusYes —Yes ↑Yes ↓Yes ↓Yes ↓Yes ↓NoNoNo
Alzoubi et al. (2013) [32]PSDMSP with MLPMale Wistar rats8 hrs/day for 6 weeksHippocampusYes —Yes ↑Yes ↓Yes ↓Yes ↓Yes ↓NoNoYes —
Alzoubi et al. (2012) [33]PSDMSP with MLPMale Wistar rats8 hrs/day for 6 weeksHippocampusYes —Yes ↑Yes ↓Yes ↓Yes ↓Yes ↓NoNoNo
Vollert et al. (2011) [34]PSDMSP with MLPMale Wistar rats24 hrsCortex, amygdala, & hippocampusNoNoNoNoNoNoNoNoYes ↑
Süer et al. (2011) [35]PSDMSP with MLPMale Wistar rats18 hrs/day for 21 daysWhole brain & hippocampusNoNoNoYes ↓NoYes ↓NoNoYes ↑
Khadrawy et al. (2011) [37]PSDMSP with MLPMale Wistar rats72 hrsCortex
Hippocampus		Yes ↓
Yes ↓		No
No		No
No		No
No		Yes —
Yes —		No
No		No
No		Yes —
Yes ↑		Yes ↑
Yes ↑
Singh and Kumar (2008) [44] PSD CP Male Wistar rats 96 hrsHippocampus, thalamus, & hypothalamusYes ↓NoNoYes —NoYes ↓NoNoYes ↑
Cerebral cortex, brain stemYes —NoNoYes —NoYes ↑NoNoYes ↓
StriatumYes —NoNoYes —NoYes —NoNoYes —
Whole brainYes ↓NoNoYes —NoYes —NoNoYes —
Das et al. (2008) [48]PSDCPMale Wistar rats96 hrsWhole brainNoNoNoNoNoNoNoNoYes ↓
D’Almeida et al. (2000) [56]PSDCPMale Wistar rats96 hrsHypothalamusYes ↓NoNoNoNoNoNoNoNo
D’Almeida et al. (1998) [57] PSD CP Male Wistar rats 96 hrsHypothalamusYes ↓NoNoNoNoNoNoNoNo
Cortex, hippocampus, thalamus, pons, & cerebellumYes —NoNoNoNoNoNoNoNo
D’Almeida et al. (1997) [58]PSDMSP with MLPMale Wistar rats96 hrsFrontal cortex
Whole brain		Yes ↓
No		No
No		No
No		No
Yes —		No
Yes —		No
Yes —		No
No		No
No		No
Yes —
Catalase: CAT, classical platform: CP, glutathione: GSH, oxidized glutathione: GSSG, glutathione peroxidase: GPx, hours: hrs, multiple large platforms: MLP, multiple small platforms: MSP, nitric oxide: NO, paradoxical sleep deprivation: PSD, superoxide dismutase: SOD, ↓: significantly reduced, ↑: significantly increased, —: not significantly increased or decreased, and ↑↑: significantly increased compared with a control and between sleep deprivation times.