Brain-Specific Superoxide Dismutase 2 Deficiency Causes Perinatal Death with Spongiform Encephalopathy in Mice

Figure 4

Impaired mitochondrial respiratory activities. Enzymatic histochemical staining for NADHD (top panels) (a, b), SDH (middle panels) (c, d), and COX activities (bottom panels) (e, f) in sagittal sections of brain from three-week-old mice of the indicated genotypes. The scale bars indicate 1 mm. (g) Quantification of enzymatic reactivities of mitochondrial complexes I, II, and IV.

(a)

(b)

(c)

(d)

(e)

(f)

(g)