Metallothionein-I/II Knockout Mice Aggravate Mitochondrial Superoxide Production and Peroxiredoxin 3 Expression in Thyroid after Excessive Iodide Exposure

Table 3

Documented literatures of iodide intake and changes of serum thyroxine (T₄) and triiodothyronine (T₃) concentrations.

Dosage of daily iodine intake	Time	Subject	Changes of serum T4, T3 concentrations	Reference
250 or 500 g	14 days	Normal volunteers	No change	[27]
1500 g	14 days	Normal volunteers	T4, T3 ↓ TSH ↑	[27]
50 or 250 mg	13 days	Normal subjects	T4, T3 ↓ TSH ↑; (within normal range)	[28]
27 mg	4 weeks	Normal volunteers	T4 within the normal range except for two subjects TSH ↑	[29]
Single doses of 10, 30, 50, and 100 mg and then daily doses of 10, 15, 30, 50, or 100 mg	12 days	Euthyroid volunteers	T3, T4 ↓ TSH ↑	[30]
190 mg	10 days	Euthyroid volunteers	T3, T4 ↓ TSH ↑	[31]
114 mg	3–7 weeks	Normal controls	T3, T4 ↓ TSH ↑	[32]
114 mg	3–7 weeks	Thyrotoxic patients	T4, T3 ↑ in some cases; other patients remained; euthyroid even after 6 weeks	[32]
114 mg	2 weeks	Hypothyroid patients on thyroxine replacement	No consistent change; (T4 ↑ at 1 and 14 days TSH ↓ the first day)	[32]