Epicatechin Reduces Striatal MPP⁺-Induced Damage in Rats through Slight Increases in SOD-Cu,Zn Activity

Figure 1

Effect of oral 100 mg/kg epicatechin (EC) on circling behavior and striatal dopamine content in MPP⁺ model. (a) Six days after MPP⁺-induced damage, the EC effect on apomorphine-induced circling behavior was evaluated. The results are expressed as mean ± S.M.E. of 6–8 animals per group. ; data were analyzed by Kruskal-Wallis’ test followed by U Mann-Whitney’s test. (b) Twenty-four hours after the behavioral test evaluation, dopamine was determined by HPLC coupled to an electrochemical detector. Results are expressed as mean ± S.E.M. of 6–8 animals per group. , two-way ANOVA followed by Tukey’s test.

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