Effects of Cyclosporine on Reperfusion Injury in Patients: A Meta-Analysis of Randomized Controlled Trials

Table 1

Characteristics of the study population.

Reference	Year	Cyclosporine method	Cyclosporine dosage	Participants	Number of subjects	Age	Study design
Chiari et al. [21]	2014	Intravenous bolus	2.5 mg/kg	Patients accepting elective aortic valve surgery	30	67 ± 11	Prospective, monocentric, randomized, controlled, single-blind
Ghaffari et al. [13]	2013	Intravenous bolus	2.5 mg/kg	Patients with acute anterior STEMI receiving TLT	50	64.0 ± 11.2	Randomized, placebo-controlled, double-blinded
Hausenloy et al. [22]	2014	Intravenous bolus	2.5 mg/kg	Patients undergoing elective CABG surgery [1]	40	65.8 ± 10.7	Randomized, placebo-controlled, double-blinded
Mewton et al. [20]	2010	Intravenous bolus	2.5 mg/kg	Patients with AMI accepting PCI	15	60 ± 10	Prospective, multicenter, randomized, controlled, single-blind
Piot et al. [12]	2008	Intravenous bolus	2.5 mg/kg	Patients with [2] AMI accepting PCI	30	58 ± 2	Prospective, multicenter, randomized, controlled, single-blind

STEMI: ST-elevation myocardial infarction; CABG: coronary artery bypass graft; AMI: acute myocardial infarction; PCI: percutaneous coronary intervention; TLT: thrombolytic treatment.