Smooth Muscle Specific Overexpression of p22phox Potentiates Carotid Artery Wall Thickening in Response to Injury
(a) Mean wall thickness in the injured and noninjured, contralateral arteries following wire injury plotted against time in the (◆: injured; ▲: control) and C57BL/6J (▼: injured; ■: control) mice. *Significant increase in mean wall thickness in C57BL/6J injured arteries versus C57BL/6J noninjured arteries at the same time points (). †Significant increase in mean wall thickness in injured arteries versus noninjured arteries at the same time points (). ‡Significant increase in mean wall thickness in injured arteries versus C57BL/6J injured arteries at the same time points (). Linear regression analysis indicates the rate of the change in wall thickness in injured carotid arteries in versus C57BL/6J mice (). (b) Mean change in carotid artery cross-sectional wall area (CSWA) 3, 7, and 14 days after injury in mice (filled bars) compared to C57BL/6J (open bars). *Significant increase in mean CSWA in injured arteries versus C57BL/6J injured arteries at the same time points (). Values represent mean ± SEM for a minimum of 8 animals per group.
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