Smooth Muscle Specific Overexpression of p22phox Potentiates Carotid Artery Wall Thickening in Response to Injury
Akt, p38MAPK, and Src phosphorylation following carotid injury in and C57BL/6J mice. The phosphorylation of Akt (ser473) (a), p38MAPK (tyr180/thr182) (b), and Src (tyr416) (c) was determined in both injured (LC) and noninjured (RC) carotid arteries collected at days 0, 3, 7, and 14 following injury. Representative immunoblots from the LC and RC are shown. Cumulative data of the LC/RC ratio are represented in the bar graphs. Values represent mean ± SEM for a minimum of 6 animals per group. A significant increase in phosphorylation following injury in carotid arteries from mice compared to C57BL/6J mice at the same time point (). Total expression of Akt, p38MAPK, and Src did not change significantly after injury and basal phosphorylation of Akt, p38MAPK, and Src was not different between noninjured arteries in wild-type and mice.
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