Oxidative Medicine and Cellular Longevity / 2015 / Article / Tab 2

Research Article

Cardiac and Vascular Synergic Protective Effect of Olea europea L. Leaves and Hibiscus sabdariffa L. Flower Extracts

Table 2

Inotropic and chronotropic effects of OEE, HSE, and their mixture.

ExtractLeft atriumRight atrium
Negative inotropyNegative chronotropy
Activitya (M ± SEM) (mg/mL)95% conf. lim.Activityc (M ± SEM) (mg/mL)95% conf. lim.

OEE68 ± 2.40.140.10–0.1837 ± 2.4
HSE76 ± 0.90.270.21–0.3546 ± 0.7d
Mixture60 ± 1.40.160.12–0.2084 ± 2.01.211.10–1.33

Decrease in developed tension on isolated guinea-pig left atrium at 1 mg/mL concentration, expressed as percent changes from the control (). The left atria were driven at 1 Hz. The 1 mg/mL concentration gave the maximum effect for most compounds. bCalculated from concentration-response curves (Probit analysis by Litchfield and Wilcoxon [46] with ). When the maximum effect was <50%, the EC50 ino., EC30 chrono., values were not calculated. cDecrease in atrial rate on guinea-pig spontaneously beating isolated right atrium 10 mg/mL concentration, expressed as percent changes from the control (). The 10 mg/mL concentration gave the maximum effect for most compounds. Pretreatment heart rate ranged from 165 to 190 beats/min. dAt 1 mg/mL concentration.

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